Proton detection of choline and lactate in EMT6 tumors by spin-echo-enhanced selective multiple-quantum-coherence transfer

Qiuhong He, Zaver M. Bhujwalla, Jerry D. Geickson

Research output: Contribution to journalArticle

Abstract

An extension of the Sel-MQC pulse sequence - SEE-SelMQC (spin-echo-enhanced selective multiple-quantum coherence transfer) - that completely suppresses lipid and water in tissues containing mobile lipid in a single scan and detects 1H resonances of multiple metabolites is described. As in the Sel-MQC lactate-editing experiments [Q. He et al., J. Magn. Reson. B 106, 203 (1995)], SEE-SelMQC acquires lactate from its ZQ → DQ coherence-transfer pathway; in addition, the method recovers signal from other metabolites by selective generation of additional spin echoes using extra frequency-selective pulses and gradients. This method introduces no loss of lactate signal intensity beyond the 50% that is lost through the multiple-quantum coherence-transfer process. The spatial distributions of choline and lactate with a phantom and in vivo, in subcutaneously implanted murine EMT6 tumors, have been simultaneously mapped.

Original languageEnglish (US)
Pages (from-to)18-25
Number of pages8
JournalJournal of Magnetic Resonance - Series B
Volume112
Issue number1
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Engineering(all)

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