TY - JOUR
T1 - Proton detection of choline and lactate in EMT6 tumors by spin-echo-enhanced selective multiple-quantum-coherence transfer
AU - He, Qiuhong
AU - Bhujwalla, Zaver M.
AU - Geickson, Jerry D.
N1 - Funding Information:
We are grateful for the financial support provided by NCI Grants CA51935 and CA51950. We thank Mr. G. Cromwell for transplanting the EMT6 tumors and maintaining the cell line, and Dr. V. P. Chacko and Dr. D. C. Shungu for assistance in instrumentation and data processing.
PY - 1996
Y1 - 1996
N2 - An extension of the Sel-MQC pulse sequence - SEE-SelMQC (spin-echo-enhanced selective multiple-quantum coherence transfer) - that completely suppresses lipid and water in tissues containing mobile lipid in a single scan and detects 1H resonances of multiple metabolites is described. As in the Sel-MQC lactate-editing experiments [Q. He et al., J. Magn. Reson. B 106, 203 (1995)], SEE-SelMQC acquires lactate from its ZQ → DQ coherence-transfer pathway; in addition, the method recovers signal from other metabolites by selective generation of additional spin echoes using extra frequency-selective pulses and gradients. This method introduces no loss of lactate signal intensity beyond the 50% that is lost through the multiple-quantum coherence-transfer process. The spatial distributions of choline and lactate with a phantom and in vivo, in subcutaneously implanted murine EMT6 tumors, have been simultaneously mapped.
AB - An extension of the Sel-MQC pulse sequence - SEE-SelMQC (spin-echo-enhanced selective multiple-quantum coherence transfer) - that completely suppresses lipid and water in tissues containing mobile lipid in a single scan and detects 1H resonances of multiple metabolites is described. As in the Sel-MQC lactate-editing experiments [Q. He et al., J. Magn. Reson. B 106, 203 (1995)], SEE-SelMQC acquires lactate from its ZQ → DQ coherence-transfer pathway; in addition, the method recovers signal from other metabolites by selective generation of additional spin echoes using extra frequency-selective pulses and gradients. This method introduces no loss of lactate signal intensity beyond the 50% that is lost through the multiple-quantum coherence-transfer process. The spatial distributions of choline and lactate with a phantom and in vivo, in subcutaneously implanted murine EMT6 tumors, have been simultaneously mapped.
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U2 - 10.1006/jmrb.1996.0104
DO - 10.1006/jmrb.1996.0104
M3 - Article
C2 - 8661302
AN - SCOPUS:0030188701
SN - 1064-1866
VL - 112
SP - 18
EP - 25
JO - Journal of Magnetic Resonance - Series B
JF - Journal of Magnetic Resonance - Series B
IS - 1
ER -