Osei-Owusu et al. show that the recently identified proton-activated chloride (PAC) channel traffics from the plasma membrane to endosomes and forms an intracellular organelle Cl− channel. PAC functions as a low pH sensor in endosomes and prevents luminal hyper-acidification.
- organellar ion channel
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)