Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis

James Osei-Owusu, Junhua Yang, Ka Ho Leung, Zheng Ruan, Wei Lü, Yamuna Krishnan, Zhaozhu Qiu

Research output: Contribution to journalArticlepeer-review

Abstract

Osei-Owusu et al. show that the recently identified proton-activated chloride (PAC) channel traffics from the plasma membrane to endosomes and forms an intracellular organelle Cl channel. PAC functions as a low pH sensor in endosomes and prevents luminal hyper-acidification.

Original languageEnglish (US)
Article number108683
JournalCell Reports
Volume34
Issue number4
DOIs
StatePublished - Jan 26 2021

Keywords

  • ASOR
  • PACC1
  • PAORAC
  • TMEM206
  • hPAC
  • organellar ion channel

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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