Abstract
Osei-Owusu et al. show that the recently identified proton-activated chloride (PAC) channel traffics from the plasma membrane to endosomes and forms an intracellular organelle Cl− channel. PAC functions as a low pH sensor in endosomes and prevents luminal hyper-acidification.
Original language | English (US) |
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Article number | 108683 |
Journal | Cell Reports |
Volume | 34 |
Issue number | 4 |
DOIs | |
State | Published - Jan 26 2021 |
Keywords
- ASOR
- PACC1
- PAORAC
- TMEM206
- hPAC
- organellar ion channel
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology