Prothrombotic states associated with retinal venous occlusion in young adults

Ahmed M. Abu El-Asrar, Abdul Kareem Al-Momen, Saleh Al-Amro, Abdel Galil M Abdel Gader, Khalid F. Tabbara

Research output: Contribution to journalArticle

Abstract

Background. The etiology of retinal venous occlusion in young patients is not well understood although thrombosis does occur histologically. A search for the risk factors that may lead to thrombosis is highly desirable may contribute to our understanding of the pathogenesis of this complication and may improve our therapeutic strategies. Methods. We studied 17 patients with retinal venous occlusion. All patients were under 45 years of age (mean 37.8 ± 7.1). Antiphospholipid antibodies (APAs) and certain hemostatic factors were determined. The results obtained in these patients were compared to those of normal controls. Results. We found APAs in 8 out of 17 patients compared to 5 out of 60 controls (p = 0.0002). In patients with major trunk occlusion, there was a trend for the presence of APAs in those with poor visual acuity at presentation. Deficiencies of the coagulation inhibitor proteins C and S and antithrombin III activities were detected in 6 patients, and reduced levels of Factor XII were found in 4 patients. Levels of hematocrit, erythrocyte sedimentation rate, Fibrinogen, α1-globulin, and α2-globulin were significantly higher in patients compared to the controls (p = 0.019; 0.014; 0.0001; 0.011; 0.047), indicating increased blood viscosity in patients with retinal venous occlusion. Conclusion: Prothrombotic changes in the form of APAs and/or deficiencies of coagulation inhibitors and Factor XII may contribute to the etiology of retinal venous occlusion in young adults. Young patients with retinal venous occlusion should be evaluated for these prothrombotic states.

Original languageEnglish (US)
Pages (from-to)197-204
Number of pages8
JournalInternational Ophthalmology
Volume20
Issue number4
StatePublished - 1996
Externally publishedYes

Fingerprint

Young Adult
Antiphospholipid Antibodies
Factor XII
Globulins
Thrombosis
Blood Viscosity
Antithrombin III
Blood Sedimentation
Protein S
Hemostatics
Hematocrit
Fibrinogen
Visual Acuity

Keywords

  • anticoagulant system
  • antiphospholipid antibodies
  • blood viscosity
  • factor XII
  • retinal vein occlusion
  • young adults

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Abu El-Asrar, A. M., Al-Momen, A. K., Al-Amro, S., Abdel Gader, A. G. M., & Tabbara, K. F. (1996). Prothrombotic states associated with retinal venous occlusion in young adults. International Ophthalmology, 20(4), 197-204.

Prothrombotic states associated with retinal venous occlusion in young adults. / Abu El-Asrar, Ahmed M.; Al-Momen, Abdul Kareem; Al-Amro, Saleh; Abdel Gader, Abdel Galil M; Tabbara, Khalid F.

In: International Ophthalmology, Vol. 20, No. 4, 1996, p. 197-204.

Research output: Contribution to journalArticle

Abu El-Asrar, AM, Al-Momen, AK, Al-Amro, S, Abdel Gader, AGM & Tabbara, KF 1996, 'Prothrombotic states associated with retinal venous occlusion in young adults', International Ophthalmology, vol. 20, no. 4, pp. 197-204.
Abu El-Asrar AM, Al-Momen AK, Al-Amro S, Abdel Gader AGM, Tabbara KF. Prothrombotic states associated with retinal venous occlusion in young adults. International Ophthalmology. 1996;20(4):197-204.
Abu El-Asrar, Ahmed M. ; Al-Momen, Abdul Kareem ; Al-Amro, Saleh ; Abdel Gader, Abdel Galil M ; Tabbara, Khalid F. / Prothrombotic states associated with retinal venous occlusion in young adults. In: International Ophthalmology. 1996 ; Vol. 20, No. 4. pp. 197-204.
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