Proteomics of pediatric heart failure: From traditional biomarkers to new discovery strategies

Mingguo Xu, Genaro A. Ramirez-Correa, Anne M. Murphy

Research output: Contribution to journalArticle

Abstract

Heart failure in children is a complex clinical syndrome with multiple aetiologies. The underlying disorders that lead to heart failure in children differ significantly from those in adults. Some clinical biomarkers for heart failure status and prognosis appear to be useful in both age groups. This review outlines the use and the present status of biomarkers for heart failure in paediatric cardiology. Furthermore, clinical scenarios in which development of new biomarkers might address management or prognosis are discussed. Finally, strategies for proteomic discovery of novel biomarkers and application to practice are described.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalCardiology in the young
Volume25
Issue numberS2
DOIs
StatePublished - Sep 17 2015

Keywords

  • Biomarker
  • heart failure
  • post-translational modification
  • proteomics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Cardiology and Cardiovascular Medicine

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