Proteomics of pediatric heart failure: From traditional biomarkers to new discovery strategies

Mingguo Xu; Genaro A. Ramirez-Correa; Anne M. Murphy

doi:10.1017/S1047951115000839

Proteomics of pediatric heart failure: From traditional biomarkers to new discovery strategies

Mingguo Xu, Genaro A. Ramirez-Correa, Anne M. Murphy

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Heart failure in children is a complex clinical syndrome with multiple aetiologies. The underlying disorders that lead to heart failure in children differ significantly from those in adults. Some clinical biomarkers for heart failure status and prognosis appear to be useful in both age groups. This review outlines the use and the present status of biomarkers for heart failure in paediatric cardiology. Furthermore, clinical scenarios in which development of new biomarkers might address management or prognosis are discussed. Finally, strategies for proteomic discovery of novel biomarkers and application to practice are described.

Original language	English (US)
Pages (from-to)	51-57
Number of pages	7
Journal	Cardiology in the young
Volume	25
Issue number	S2
DOIs	https://doi.org/10.1017/S1047951115000839
State	Published - Sep 17 2015

Keywords

Biomarker
heart failure
post-translational modification
proteomics

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Cardiology and Cardiovascular Medicine

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10.1017/S1047951115000839

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abstract = "Heart failure in children is a complex clinical syndrome with multiple aetiologies. The underlying disorders that lead to heart failure in children differ significantly from those in adults. Some clinical biomarkers for heart failure status and prognosis appear to be useful in both age groups. This review outlines the use and the present status of biomarkers for heart failure in paediatric cardiology. Furthermore, clinical scenarios in which development of new biomarkers might address management or prognosis are discussed. Finally, strategies for proteomic discovery of novel biomarkers and application to practice are described.",

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AU - Ramirez-Correa, Genaro A.

AU - Murphy, Anne M.

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PY - 2015/9/17

Y1 - 2015/9/17

N2 - Heart failure in children is a complex clinical syndrome with multiple aetiologies. The underlying disorders that lead to heart failure in children differ significantly from those in adults. Some clinical biomarkers for heart failure status and prognosis appear to be useful in both age groups. This review outlines the use and the present status of biomarkers for heart failure in paediatric cardiology. Furthermore, clinical scenarios in which development of new biomarkers might address management or prognosis are discussed. Finally, strategies for proteomic discovery of novel biomarkers and application to practice are described.

AB - Heart failure in children is a complex clinical syndrome with multiple aetiologies. The underlying disorders that lead to heart failure in children differ significantly from those in adults. Some clinical biomarkers for heart failure status and prognosis appear to be useful in both age groups. This review outlines the use and the present status of biomarkers for heart failure in paediatric cardiology. Furthermore, clinical scenarios in which development of new biomarkers might address management or prognosis are discussed. Finally, strategies for proteomic discovery of novel biomarkers and application to practice are described.

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KW - post-translational modification

KW - proteomics

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Proteomics of pediatric heart failure: From traditional biomarkers to new discovery strategies

Abstract

Keywords

ASJC Scopus subject areas

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