Proteomics of human bile

Troels Zakarias Kristiansen; Anirban Maitra; Akhilesh Pandey

doi:10.1007/978-1-59745-432-2_18

Proteomics of human bile

Troels Zakarias Kristiansen, Anirban Maitra, Akhilesh Pandey

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

7 Scopus citations

Abstract

Bile is an important body fluid with crucial functions ranging from fat absorption to excretion of metabolic breakdown products. Although the chemical composition of human bile is well understood, its protein constituents are beginning to be unravelled only recently. Here, we provide an overview of the proteomics of human bile, both in health and in diseases such as cholangiocarcinoma. A comprehensive catalog of proteins in the bile should facilitate better understanding of its role in physiology and the development and validation of biomarkers for hepatobiliary disorders.

Original language	English (US)
Title of host publication	Proteomics of Human Body Fluids: Principles, Methods, and Applications
Publisher	Humana Press Inc.
Pages	399-414
Number of pages	16
ISBN (Print)	9781597454322, 9781588296573
DOIs	https://doi.org/10.1007/978-1-59745-432-2_18
State	Published - 2007

Keywords

Bile
biomarker discovery
hepatobiliary cancer
LC-MS/MS
mass spectrometry
proteomics

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-59745-432-2_18

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AU - Kristiansen, Troels Zakarias

AU - Maitra, Anirban

AU - Pandey, Akhilesh

PY - 2007

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AB - Bile is an important body fluid with crucial functions ranging from fat absorption to excretion of metabolic breakdown products. Although the chemical composition of human bile is well understood, its protein constituents are beginning to be unravelled only recently. Here, we provide an overview of the proteomics of human bile, both in health and in diseases such as cholangiocarcinoma. A comprehensive catalog of proteins in the bile should facilitate better understanding of its role in physiology and the development and validation of biomarkers for hepatobiliary disorders.

KW - Bile

KW - biomarker discovery

KW - hepatobiliary cancer

KW - LC-MS/MS

KW - mass spectrometry

KW - proteomics

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M3 - Chapter

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SN - 9781597454322

SN - 9781588296573

SP - 399

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BT - Proteomics of Human Body Fluids: Principles, Methods, and Applications

PB - Humana Press Inc.

ER -

Proteomics of human bile

Abstract

Keywords

ASJC Scopus subject areas

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