Proteomics in transplantation

Katrin Kienzl-Wagner, Gerald Brandacher

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Proteomics and biochemical profiling have emerged as exciting and powerful tools in clinical biomarker research. In the field of transplantation, proteomics aims not only at developing noninvasive means for immune monitoring but also to gain mechanistic insights into the pathophysiology of the alloimmune response and hence defining new therapeutic targets. This chapter provides an overview of proteomic biomarker-driven approaches and its underlying concepts and discusses the advantages, clinical implications, challenges, and limitations of this novel modality as it relates to solid organ transplantation.

Original languageEnglish (US)
Title of host publicationAdvances in Clinical Chemistry
PublisherAcademic Press Inc.
Pages215-244
Number of pages30
DOIs
StatePublished - Jan 1 2014

Publication series

NameAdvances in Clinical Chemistry
Volume67
ISSN (Print)0065-2423

Keywords

  • Biomarker
  • Diagnosis
  • Immunosuppression
  • Proteomics
  • Rejection
  • Transplantation

ASJC Scopus subject areas

  • Chemistry(all)
  • Clinical Biochemistry

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