Proteomics: A new diagnostic frontier

Glen L. Hortin, Saeed A. Jortani, James C. Ritchie, Roland Valdes, Daniel Wan-Yui Chan

Research output: Contribution to journalArticle

Abstract

Background: Analysis of proteins has been an integral part of the field of clinical chemistry for decades. Recent advances in technology and complete identification of the human genome sequence have opened up new opportunities for analysis of proteins for clinical diagnostic purposes. Methods: Content of a recent conference of proteomics is summarized. Results: New analytical methods allow the simultaneous analysis of a large number of proteins in biological fluids such as serum and plasma, offering partial views of the complete set of proteins or proteome. Plasma presents many analytical challenges, such as the complexity of components, predominance of a few major components, and the large concentration range of components, but the number of proteins that can be detected in plasma has expanded dramatically from hundreds to thousands. At the same time, there is increased capability to detect structural variations of proteins. Recent studies also identified the presence of complex sets of small protein fragments in plasma. This set of protein fragments, the fragmentome or peptidome, is potentially a rich source of information about physiologic and disease processes. Conclusions: Advances in proteomics offer great promise for the discovery of markers that might serve as the basis for new clinical laboratory tests. There are many challenges, however, in the translation of newly discovered markers into clinical laboratory tests.

Original languageEnglish (US)
Pages (from-to)1218-1222
Number of pages5
JournalClinical Chemistry
Volume52
Issue number7
DOIs
StatePublished - Jul 2006

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Proteomics
Proteins
Clinical laboratories
Plasmas
Clinical Chemistry
Human Genome
Proteome
Genes
Biomarkers
Technology
Fluids
Serum

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Hortin, G. L., Jortani, S. A., Ritchie, J. C., Valdes, R., & Chan, D. W-Y. (2006). Proteomics: A new diagnostic frontier. Clinical Chemistry, 52(7), 1218-1222. https://doi.org/10.1373/clinchem.2006.067280

Proteomics : A new diagnostic frontier. / Hortin, Glen L.; Jortani, Saeed A.; Ritchie, James C.; Valdes, Roland; Chan, Daniel Wan-Yui.

In: Clinical Chemistry, Vol. 52, No. 7, 07.2006, p. 1218-1222.

Research output: Contribution to journalArticle

Hortin, GL, Jortani, SA, Ritchie, JC, Valdes, R & Chan, DW-Y 2006, 'Proteomics: A new diagnostic frontier', Clinical Chemistry, vol. 52, no. 7, pp. 1218-1222. https://doi.org/10.1373/clinchem.2006.067280
Hortin GL, Jortani SA, Ritchie JC, Valdes R, Chan DW-Y. Proteomics: A new diagnostic frontier. Clinical Chemistry. 2006 Jul;52(7):1218-1222. https://doi.org/10.1373/clinchem.2006.067280
Hortin, Glen L. ; Jortani, Saeed A. ; Ritchie, James C. ; Valdes, Roland ; Chan, Daniel Wan-Yui. / Proteomics : A new diagnostic frontier. In: Clinical Chemistry. 2006 ; Vol. 52, No. 7. pp. 1218-1222.
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