Proteomics-a blessing or a curse? application of proteomics technology to transplant medicine

Katrin Kienzl-Wagner, Johann Pratschke, Gerald Brandacher

Research output: Contribution to journalReview article

Abstract

Proteomics has emerged as a powerful tool in clinical biomarker research. In the field of transplantation, proteomics aims not only at developing noninvasive tools for immune monitoring and identifying biomarkers of allograft rejection but also to gain mechanistic insights into the pathophysiology of an alloimmune response and hence defining new therapeutic targets. A basic knowledge of proteomic technology is a prerequisite to appreciate the complex data generated and required for critical evaluation/interpretation of proteomic-driven studies. This review provides an overview of proteomic approaches and its underlying concepts and discusses the advantages, clinical implications, challenges, and limitations of this exciting modality in transplantation.

Original languageEnglish (US)
Pages (from-to)499-509
Number of pages11
JournalTransplantation
Volume92
Issue number5
DOIs
StatePublished - Sep 15 2011

    Fingerprint

Keywords

  • Biomarker
  • Proteomics
  • Transplantation

ASJC Scopus subject areas

  • Transplantation

Cite this