Proteomic analysis of cancer-cell mitochondria

Mukesh Verma; Jacob Kagan; David Sidransky; Sudhir Srivastava

doi:10.1038/nrc1192

Proteomic analysis of cancer-cell mitochondria

Mukesh Verma, Jacob Kagan, David Sidransky, Sudhir Srivastava

School of Medicine

Research output: Contribution to journal › Review article › peer-review

83 Scopus citations

Abstract

Mitochondrial dysfunction and mutations in mitochondrial DNA have been frequently reported in cancer cells. Mitochondrial gene-expression signatures of transformed cells have been identified; however, the phenotypic effects of these genetic alterations remain to be established. Identification of mitochondrial proteins that are aberrantly expressed in cancer cells has been made possible by the recent development of mitochonddal functional proteomics and could identify new markers for early detection and risk assessment, as well as targets for therapeutic intervention.

Original language	English (US)
Pages (from-to)	789-795
Number of pages	7
Journal	Nature Reviews Cancer
Volume	3
Issue number	10
DOIs	https://doi.org/10.1038/nrc1192
State	Published - Oct 2003

ASJC Scopus subject areas

Oncology
Cancer Research

Access to Document

10.1038/nrc1192

Cite this

@article{4cac288aa09042d3a5d070f49900fa94,

title = "Proteomic analysis of cancer-cell mitochondria",

abstract = "Mitochondrial dysfunction and mutations in mitochondrial DNA have been frequently reported in cancer cells. Mitochondrial gene-expression signatures of transformed cells have been identified; however, the phenotypic effects of these genetic alterations remain to be established. Identification of mitochondrial proteins that are aberrantly expressed in cancer cells has been made possible by the recent development of mitochonddal functional proteomics and could identify new markers for early detection and risk assessment, as well as targets for therapeutic intervention.",

author = "Mukesh Verma and Jacob Kagan and David Sidransky and Sudhir Srivastava",

note = "Funding Information: We thank R. Beijersbergen for helpful discussions and critical reading of this manuscript and apologize to our colleagues for omission of relevant work due to space constraints. The work of the authors was supported by grants from the Dutch Cancer Society, The Netherlands Organization for Scientific Research and the Center for Biomedical Genetics.",

year = "2003",

month = oct,

doi = "10.1038/nrc1192",

language = "English (US)",

volume = "3",

pages = "789--795",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

number = "10",

}

TY - JOUR

T1 - Proteomic analysis of cancer-cell mitochondria

AU - Verma, Mukesh

AU - Kagan, Jacob

AU - Sidransky, David

AU - Srivastava, Sudhir

N1 - Funding Information: We thank R. Beijersbergen for helpful discussions and critical reading of this manuscript and apologize to our colleagues for omission of relevant work due to space constraints. The work of the authors was supported by grants from the Dutch Cancer Society, The Netherlands Organization for Scientific Research and the Center for Biomedical Genetics.

PY - 2003/10

Y1 - 2003/10

N2 - Mitochondrial dysfunction and mutations in mitochondrial DNA have been frequently reported in cancer cells. Mitochondrial gene-expression signatures of transformed cells have been identified; however, the phenotypic effects of these genetic alterations remain to be established. Identification of mitochondrial proteins that are aberrantly expressed in cancer cells has been made possible by the recent development of mitochonddal functional proteomics and could identify new markers for early detection and risk assessment, as well as targets for therapeutic intervention.

AB - Mitochondrial dysfunction and mutations in mitochondrial DNA have been frequently reported in cancer cells. Mitochondrial gene-expression signatures of transformed cells have been identified; however, the phenotypic effects of these genetic alterations remain to be established. Identification of mitochondrial proteins that are aberrantly expressed in cancer cells has been made possible by the recent development of mitochonddal functional proteomics and could identify new markers for early detection and risk assessment, as well as targets for therapeutic intervention.

UR - http://www.scopus.com/inward/record.url?scp=0142197219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142197219&partnerID=8YFLogxK

U2 - 10.1038/nrc1192

DO - 10.1038/nrc1192

M3 - Review article

C2 - 14570046

AN - SCOPUS:0142197219

SN - 1474-175X

VL - 3

SP - 789

EP - 795

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 10

ER -

Proteomic analysis of cancer-cell mitochondria

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this