Proteome of the anterior segment structure in relation to glaucoma

Rachida A. Bouhenni, Deepak P. Edward

Research output: Contribution to journalArticlepeer-review

Abstract

Glaucoma is a heterogeneous group of diseases that is characterized by structural changes in the optic nerve head, which can lead to blindness. Although the endpoint pathology in glaucoma is damage to the retinal ganglion cells and optic nerve, glaucoma also involves tissues in the anterior segment. The pathogenesis of glaucoma has been widely studied; however, the mechanisms causing it are not completely understood. Proteomic approaches have provided new insights into the pathogenesis of glaucoma. These technologies have helped to identify changes in the extracellular matrix and alterations in cytoskeletal proteins of the trabecular meshwork, in addition to the role of autoimmunity and oxidative damage. In this review, we describe the proteomic approaches that have been used to study protein alterations in the anterior segment as related to glaucoma in addition to some of the mechanisms that these technologies have helped to elucidate.

Original languageEnglish (US)
Pages (from-to)143-153
Number of pages11
JournalProteomics - Clinical Applications
Volume8
Issue number3-4
DOIs
StatePublished - 2014

Keywords

  • Anterior
  • Glaucoma
  • Segment

ASJC Scopus subject areas

  • Clinical Biochemistry

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