Proteolytic enzymes in salivary extravasation mucoceles

Masayuki Azuma, Tetsuya Tamatani, Kazuhiro Fukui, Tokuyuki Yuki, Mohammad Obaidul Hoque, Hideo Yoshida, Mitsunobu Sato

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


We examined the content of type IV collagenases and plasminogen activators (PAs) in luminal fluid of four extravasation mucoceles by means of gelatin or casein zymography. Immunohistochemical staining for type IV collagenases and PAs was performed to identify the possible source of these enzymes. The luminal fluid examined by gelatin zymography showed a high level of type IV collagenases compared with saliva from Wharton's duct. PAs were detected in only one of the cases by casein zymography, and none was detected in the saliva. By immunohistochemical staining, type IV collagenases and PAs were detected in duct and myoepithelial cells of the adjacent salivary gland and in macrophages and fibro‐blasts of the cyst wall. The results suggest that proteolytic enzymes are involved in the pathogenesis of mucoceles.

Original languageEnglish (US)
Pages (from-to)299-302
Number of pages4
JournalJournal of Oral Pathology & Medicine
Issue number7
StatePublished - Aug 1995
Externally publishedYes


  • collagenases
  • mucocele
  • plasminogen activators

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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