Proteinuria and the nephrotic syndrome in homozygous sickle cell anaemia

G. D. Nicholson, U. F. Amin, G. A O Alleyne

Research output: Contribution to journalArticle

Abstract

Thirteen patients with homozygous sickle cell anaemia (SCA) and clinical and laboratory evidence of renal glomerular disease were studied in an attempt to determine the pathogenesis of proteinuria and the nephrotic syndrome in this group of patients. Correlation was made between the clinical presentation and the renal histological changes in assigning the patients to various groups. Patients with active leg ulcers and acute presentations showed evidence of poststreptococcal glomerulonephritis and spontaneous resolution of the renal disease in the majority of cases. Other groups showed persistent proteinuria and/or progressive deterioration of renal function. Serological evidence of streptococcal infection was present in all groups regardless of whether the renal histology showed a proliferative or membranoproliferative glomerulonephritis. It is concluded that streptococcal glomerulonephritis is an important cause of proteinuria and the nephrotic syndrome in SCA and that chronic leg ulceration may facilitate the acquisition of such diseases.

Original languageEnglish (US)
Pages (from-to)239-246
Number of pages8
JournalWest Indian Medical Journal
Volume29
Issue number4
StatePublished - 1980
Externally publishedYes

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Nephrotic Syndrome
Sickle Cell Anemia
Proteinuria
Kidney
Glomerulonephritis
Membranoproliferative Glomerulonephritis
Streptococcal Infections
Leg Ulcer
Leg
Histology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Nicholson, G. D., Amin, U. F., & Alleyne, G. A. O. (1980). Proteinuria and the nephrotic syndrome in homozygous sickle cell anaemia. West Indian Medical Journal, 29(4), 239-246.

Proteinuria and the nephrotic syndrome in homozygous sickle cell anaemia. / Nicholson, G. D.; Amin, U. F.; Alleyne, G. A O.

In: West Indian Medical Journal, Vol. 29, No. 4, 1980, p. 239-246.

Research output: Contribution to journalArticle

Nicholson, GD, Amin, UF & Alleyne, GAO 1980, 'Proteinuria and the nephrotic syndrome in homozygous sickle cell anaemia', West Indian Medical Journal, vol. 29, no. 4, pp. 239-246.
Nicholson, G. D. ; Amin, U. F. ; Alleyne, G. A O. / Proteinuria and the nephrotic syndrome in homozygous sickle cell anaemia. In: West Indian Medical Journal. 1980 ; Vol. 29, No. 4. pp. 239-246.
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