Proteinuria: abate or applaud abatacept in proteinuric kidney disease?

Jochen Reiser; Nada Alachkar

doi:10.1038/nrneph.2013.276

Proteinuria: abate or applaud abatacept in proteinuric kidney disease?

Jochen Reiser, Nada Alachkar

School of Medicine

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

T-lymphocyte activation antigen CD80 is a B-cell costimulator and podocyte injury marker originally described in lupus nephritis; CD80 blockade with abatacept disappointed in a lupus nephritis trial. A study now suggests abatacept efficacy in focal and segmental glomerulosclerosis. Small patient numbers and concurrent treatment regimens call for more definitive studies regarding this therapeutic strategy.

Original language	English (US)
Pages (from-to)	128-130
Number of pages	3
Journal	Nature reviews. Nephrology
Volume	10
Issue number	3
DOIs	https://doi.org/10.1038/nrneph.2013.276
State	Published - Mar 2014

ASJC Scopus subject areas

Nephrology

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10.1038/nrneph.2013.276

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title = "Proteinuria: abate or applaud abatacept in proteinuric kidney disease?",

abstract = "T-lymphocyte activation antigen CD80 is a B-cell costimulator and podocyte injury marker originally described in lupus nephritis; CD80 blockade with abatacept disappointed in a lupus nephritis trial. A study now suggests abatacept efficacy in focal and segmental glomerulosclerosis. Small patient numbers and concurrent treatment regimens call for more definitive studies regarding this therapeutic strategy.",

author = "Jochen Reiser and Nada Alachkar",

note = "Funding Information: M. Tonelli is supported by a Government of Canada research chair in the optimal care of people with chronic kidney disease.",

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AU - Alachkar, Nada

N1 - Funding Information: M. Tonelli is supported by a Government of Canada research chair in the optimal care of people with chronic kidney disease.

PY - 2014/3

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N2 - T-lymphocyte activation antigen CD80 is a B-cell costimulator and podocyte injury marker originally described in lupus nephritis; CD80 blockade with abatacept disappointed in a lupus nephritis trial. A study now suggests abatacept efficacy in focal and segmental glomerulosclerosis. Small patient numbers and concurrent treatment regimens call for more definitive studies regarding this therapeutic strategy.

AB - T-lymphocyte activation antigen CD80 is a B-cell costimulator and podocyte injury marker originally described in lupus nephritis; CD80 blockade with abatacept disappointed in a lupus nephritis trial. A study now suggests abatacept efficacy in focal and segmental glomerulosclerosis. Small patient numbers and concurrent treatment regimens call for more definitive studies regarding this therapeutic strategy.

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Proteinuria: abate or applaud abatacept in proteinuric kidney disease?

Abstract

ASJC Scopus subject areas

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