Proteins that bind A-type lamins

Integrating isolated clues

Michael S. Zastrow, Sylvia Vlcek, Katherine Lee Wilson

Research output: Contribution to journalArticle

Abstract

What do such diverse molecules as DNA, actin, retinoblastoma protein and protein kinase Cα all have in common? They and additional partners bind 'A-type' lamins, which form stable filaments in animal cell nuclei. Mutations in A-type lamins cause a bewildering range of tissue-specific diseases, termed 'laminopathies', including Emery-Dreifuss muscular dystrophy and the devastating Hutchinson-Gilford progeria syndrome, which mimics premature aging. Considered individually and collectively, partners for A-type lamins form four loose groups: architectural partners, chromatin partners, gene-regulatory partners and signaling partners. We describe 16 partners in detail, summarize their binding sites in A-type lamins, and sketch portraits of ternary complexes and functional pathways that might depend on lamins in vivo. On the basis of our limited current knowledge, we propose lamin-associated complexes with multiple components relevant to nuclear structure (e.g. emerin, nesprin 1α, actin) or signaling and gene regulation (e.g. LAP2α, retinoblastoma, E2F-DP heterodimers, genes) as 'food for thought'. Testing these ideas will deepen our understanding of nuclear function and human disease.

Original languageEnglish (US)
Pages (from-to)979-987
Number of pages9
JournalJournal of Cell Science
Volume117
Issue number7
DOIs
StatePublished - Mar 1 2004

Fingerprint

Lamin Type A
Lamins
Actins
Proteins
Emery-Dreifuss Muscular Dystrophy
Progeria
Premature Aging
Retinoblastoma Protein
Retinoblastoma
Regulator Genes
Cell Nucleus
Protein Kinase C
Genes
Chromatin
Binding Sites
Mutation
DNA

Keywords

  • Emerin
  • Emery-Dreifuss muscular dystrophy
  • Hutchinson-Gilford progeria syndrome
  • Laminopathy
  • Nuclear envelope

ASJC Scopus subject areas

  • Cell Biology

Cite this

Proteins that bind A-type lamins : Integrating isolated clues. / Zastrow, Michael S.; Vlcek, Sylvia; Wilson, Katherine Lee.

In: Journal of Cell Science, Vol. 117, No. 7, 01.03.2004, p. 979-987.

Research output: Contribution to journalArticle

Zastrow, Michael S. ; Vlcek, Sylvia ; Wilson, Katherine Lee. / Proteins that bind A-type lamins : Integrating isolated clues. In: Journal of Cell Science. 2004 ; Vol. 117, No. 7. pp. 979-987.
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