TY - JOUR
T1 - Proteinase-3 and myeloperoxidase serotype in relation to demographic factors and geographic distribution in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis
AU - Weiner, Maria
AU - Bjørneklett, Rune
AU - Hrusková, Zdenka
AU - Mackinnon, Bruce
AU - Poulton, Caroline J.
AU - Sindelar, Leo
AU - Mohammad, Aladdin J.
AU - Eriksson, Per
AU - Gesualdo, Loreto
AU - Geetha, Duvuru
AU - Crnogorac, Matija
AU - Jayne, David
AU - Hogan, Susan L.
AU - Geddes, Colin
AU - Tesar, Vladimir
AU - Aasarød, Knut
AU - Segelmark, Mårten
N1 - Funding Information:
This work was supported by the Ingrid Asp Foundation (to M.S.), the Swedish Renal Foundation (to M.W.), the Swedish Society of Medicine (Svenska Läkaresällskapet) and the Swedish Rheumatism Association (Reumatikerförbundet) (to A.J.M.). The GDCN registry was supported in part by Program Project Grant P01-DK5-30834 from the National Institute for Diabetes and Digestive and Kidney Diseases of the National Institutes of Health, Bethesda, MD, USA.
Funding Information:
The project was launched by the European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Immunology Work Group (IWG). STRÅNG data used are from the Swedish Meteorological and Hydrological Institute (SMHI) and were produced with support from the Swedish Radiation Protection Authority and the Swedish Environmental Agency. The authors would like to thank all centres, research nurses and physicians who contributed data to the Czech Registry of ANCA-associated vasculitides; Shunsuke Furuta, Addenbrooke’s Hospital, Vasculitis and Lupus Clinic in Cambridge for his contributions to the vasculitis registry in Cambridge; Emily McQuarrie for her contributions to the Scottish biopsy registry in Glasgow; Ronald J. Falk, J. Charles Jennette and Patrick H. Nachman, University of North Carolina, for their contributions to the GDCN registry and Kresimir Galesic and Ivica Horvatic for their contributions to the renal biopsy registry at Dubrava University Hospital.
Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Background: In anti-neutrophil cytoplasmic antibody (ANCA)associated glomerulonephritis, antigen specificity varies between myeloperoxidase (MPO) and proteinase 3 (PR3). This has been reported to vary in relation to age, gender, geography and extrarenal manifestations. However, studies are difficult to compare as criteria for inclusion vary. The aim of this study was to investigate the relationship between ANCA serotype, latitude, ultraviolet (UV) radiation levels, age, gender and renal function at diagnosis in a large study with uniform inclusion criteria. Methods: Patients with biopsy-proven ANCA-associated glomerulonephritis were identified from regional or nationwide registries in 14 centres in Norway, Sweden, the UK, the Czech Republic, Croatia, Italy and the USA during the period 2000-13. UV radiation levels for 2000-13 in Europe were obtained from the Swedish Meteorological and Hydrological Institute. Results: A total of 1408 patients (45.2% PR3-ANCA) were included in the study. In univariable analysis, PR3-ANCA was significantly associated with male gender {odds ratio [OR] 2.12 [95% confidence interval (CI) 1.71-2.62]}, younger age [OR per year 0.97 (95% CI 0.96-0.98)] and higher glomerular filtration rate [OR per mL/min 1.01 (95% CI 1.01-1.02); P < 0.001] at diagnosis but not with latitude or UV radiation. In multivariable logistic regression analysis, latitude and UV radiation also became significant, with higher odds for PR3-ANCA positivity at northern latitudes/lower UV radiation levels. However, the latitudinal difference in MPO:PR3 ratio is smaller than differences previously reported concerning microscopic polyangiitis and granulomatosis with polyangiitis. Conclusions: The ratio between PR3-ANCA and MPO-ANCA varies in glomerulonephritis with respect to age, gender, renal function and geographic latitude/UV radiation levels.
AB - Background: In anti-neutrophil cytoplasmic antibody (ANCA)associated glomerulonephritis, antigen specificity varies between myeloperoxidase (MPO) and proteinase 3 (PR3). This has been reported to vary in relation to age, gender, geography and extrarenal manifestations. However, studies are difficult to compare as criteria for inclusion vary. The aim of this study was to investigate the relationship between ANCA serotype, latitude, ultraviolet (UV) radiation levels, age, gender and renal function at diagnosis in a large study with uniform inclusion criteria. Methods: Patients with biopsy-proven ANCA-associated glomerulonephritis were identified from regional or nationwide registries in 14 centres in Norway, Sweden, the UK, the Czech Republic, Croatia, Italy and the USA during the period 2000-13. UV radiation levels for 2000-13 in Europe were obtained from the Swedish Meteorological and Hydrological Institute. Results: A total of 1408 patients (45.2% PR3-ANCA) were included in the study. In univariable analysis, PR3-ANCA was significantly associated with male gender {odds ratio [OR] 2.12 [95% confidence interval (CI) 1.71-2.62]}, younger age [OR per year 0.97 (95% CI 0.96-0.98)] and higher glomerular filtration rate [OR per mL/min 1.01 (95% CI 1.01-1.02); P < 0.001] at diagnosis but not with latitude or UV radiation. In multivariable logistic regression analysis, latitude and UV radiation also became significant, with higher odds for PR3-ANCA positivity at northern latitudes/lower UV radiation levels. However, the latitudinal difference in MPO:PR3 ratio is smaller than differences previously reported concerning microscopic polyangiitis and granulomatosis with polyangiitis. Conclusions: The ratio between PR3-ANCA and MPO-ANCA varies in glomerulonephritis with respect to age, gender, renal function and geographic latitude/UV radiation levels.
KW - ANCA-associated vasculitis
KW - Glomerulonephritis
KW - Latitude
KW - MPO-ANCA
KW - PR3-ANCA
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M3 - Article
C2 - 29718465
AN - SCOPUS:85061512305
SN - 0931-0509
VL - 34
SP - 301
EP - 308
JO - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
JF - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
IS - 2
ER -