Abstract
Csk and Src are two protein tyrosine kinases with similar amino acid sequences but very different structures and functions. Csk catalyzes a tail phosphorylation reaction on Src and thereby restrains Src's activity and oncogenic potential. Comparative analysis of the domain interactions in these enzymes provides a lesson in signalling diversity and mechanisms of enzyme regulation. The molecular basis of the specificity of Csk targeting the Src tail appears to involve both local and long-range interactions and illustrates the complexity of selective targeting in post-translational modification.
Original language | English (US) |
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Pages (from-to) | 580-585 |
Number of pages | 6 |
Journal | Current Opinion in Chemical Biology |
Volume | 7 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2003 |
Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry