Protein tyrosine kinase-substrate interactions

Ron Bose, Marc A. Holbert, Kerry A. Pickin, Philip A. Cole

Research output: Contribution to journalArticle

Abstract

Protein tyrosine kinases (PTKs) are enzymes that catalyze the phosphorylation of tyrosyl residues. They are important in physiological and pathophysiological processes. Protein substrates of PTKs are often difficult to discern, but recently reported methods have helped to identify targets and characterize their structural interactions with kinases. A mechanism-based bisubstrate analog strategy has given X-ray crystallographic insights into how several topical PTKs, including the insulin receptor, Abl and epidermal growth factor receptor, interact with tyrosine-containing peptide substrates. These PTK co-crystal structures reveal both conserved and specialized features of recognition that probably contribute to substrate selection and the individual functions of these key enzymes.

Original languageEnglish (US)
Pages (from-to)668-675
Number of pages8
JournalCurrent Opinion in Structural Biology
Volume16
Issue number6
DOIs
StatePublished - Dec 2006

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Protein-Tyrosine Kinases
Physiological Phenomena
Insulin Receptor
Enzymes
Epidermal Growth Factor Receptor
Tyrosine
Phosphotransferases
Phosphorylation
X-Rays
Peptides
Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

Bose, R., Holbert, M. A., Pickin, K. A., & Cole, P. A. (2006). Protein tyrosine kinase-substrate interactions. Current Opinion in Structural Biology, 16(6), 668-675. https://doi.org/10.1016/j.sbi.2006.10.012

Protein tyrosine kinase-substrate interactions. / Bose, Ron; Holbert, Marc A.; Pickin, Kerry A.; Cole, Philip A.

In: Current Opinion in Structural Biology, Vol. 16, No. 6, 12.2006, p. 668-675.

Research output: Contribution to journalArticle

Bose, R, Holbert, MA, Pickin, KA & Cole, PA 2006, 'Protein tyrosine kinase-substrate interactions', Current Opinion in Structural Biology, vol. 16, no. 6, pp. 668-675. https://doi.org/10.1016/j.sbi.2006.10.012
Bose, Ron ; Holbert, Marc A. ; Pickin, Kerry A. ; Cole, Philip A. / Protein tyrosine kinase-substrate interactions. In: Current Opinion in Structural Biology. 2006 ; Vol. 16, No. 6. pp. 668-675.
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