Abstract
Background: One of the signaling mechanisms mediated by nitric oxide (NO) is through S-nitrosylation, the reversible redox-based modification of cysteine residues, on target proteins that regulate a myriad of physiological and pathophysiological processes. In particular, an increasing number of studies have identified important roles for S-nitrosylation in regulating cell death. Scope of review: The present review focuses on different targets and functional consequences associated with nitric oxide and protein S-nitrosylation during neuronal cell death. Major conclusions: S-Nitrosylation exhibits double-edged effects dependent on the levels, spatiotemporal distribution, and origins of NO in the brain: in general Snitrosylation resulting from the basal low level of NO in cells exerts anti-cell death effects, whereas S-nitrosylation elicited by induced NO upon stressed conditions is implicated in pro-cell death effects. General Significance: Dysregulated protein S-nitrosylation is implicated in the pathogenesis of several diseases including degenerative diseases of the central nervous system (CNS). Elucidating specific targets of S-nitrosylation as well as their regulatory mechanisms may aid in the development of therapeutic intervention in a wide range of brain diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 736-742 |
| Number of pages | 7 |
| Journal | Biochimica et Biophysica Acta - General Subjects |
| Volume | 1820 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2012 |
Fingerprint
Keywords
- Apoptosis
- Caspase
- GAPDH
- Nitric oxide
- S-nitrosylation
- XIAP
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Protein S-nitrosylation : Role for nitric oxide signaling in neuronal death. / Shahani, Neelam; Sawa, Akira.
In: Biochimica et Biophysica Acta - General Subjects, Vol. 1820, No. 6, 06.2012, p. 736-742.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Protein S-nitrosylation
T2 - Role for nitric oxide signaling in neuronal death
AU - Shahani, Neelam
AU - Sawa, Akira
PY - 2012/6
Y1 - 2012/6
N2 - Background: One of the signaling mechanisms mediated by nitric oxide (NO) is through S-nitrosylation, the reversible redox-based modification of cysteine residues, on target proteins that regulate a myriad of physiological and pathophysiological processes. In particular, an increasing number of studies have identified important roles for S-nitrosylation in regulating cell death. Scope of review: The present review focuses on different targets and functional consequences associated with nitric oxide and protein S-nitrosylation during neuronal cell death. Major conclusions: S-Nitrosylation exhibits double-edged effects dependent on the levels, spatiotemporal distribution, and origins of NO in the brain: in general Snitrosylation resulting from the basal low level of NO in cells exerts anti-cell death effects, whereas S-nitrosylation elicited by induced NO upon stressed conditions is implicated in pro-cell death effects. General Significance: Dysregulated protein S-nitrosylation is implicated in the pathogenesis of several diseases including degenerative diseases of the central nervous system (CNS). Elucidating specific targets of S-nitrosylation as well as their regulatory mechanisms may aid in the development of therapeutic intervention in a wide range of brain diseases.
AB - Background: One of the signaling mechanisms mediated by nitric oxide (NO) is through S-nitrosylation, the reversible redox-based modification of cysteine residues, on target proteins that regulate a myriad of physiological and pathophysiological processes. In particular, an increasing number of studies have identified important roles for S-nitrosylation in regulating cell death. Scope of review: The present review focuses on different targets and functional consequences associated with nitric oxide and protein S-nitrosylation during neuronal cell death. Major conclusions: S-Nitrosylation exhibits double-edged effects dependent on the levels, spatiotemporal distribution, and origins of NO in the brain: in general Snitrosylation resulting from the basal low level of NO in cells exerts anti-cell death effects, whereas S-nitrosylation elicited by induced NO upon stressed conditions is implicated in pro-cell death effects. General Significance: Dysregulated protein S-nitrosylation is implicated in the pathogenesis of several diseases including degenerative diseases of the central nervous system (CNS). Elucidating specific targets of S-nitrosylation as well as their regulatory mechanisms may aid in the development of therapeutic intervention in a wide range of brain diseases.
KW - Apoptosis
KW - Caspase
KW - GAPDH
KW - Nitric oxide
KW - S-nitrosylation
KW - XIAP
UR - http://www.scopus.com/inward/record.url?scp=84860484051&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860484051&partnerID=8YFLogxK
U2 - 10.1016/j.bbagen.2011.07.010
DO - 10.1016/j.bbagen.2011.07.010
M3 - Article
C2 - 21803124
AN - SCOPUS:84860484051
VL - 1820
SP - 736
EP - 742
JO - Biochimica et Biophysica Acta - General Subjects
JF - Biochimica et Biophysica Acta - General Subjects
SN - 0304-4165
IS - 6
ER -