Protein quality control and degradation in cardiomyocytes

Xuejun Wang, Huabo Su, Mark Ranek

Research output: Contribution to journalReview article

Abstract

The heart is constantly under stress and cardiomyocytes face enormous challenges to correctly fold nascent polypeptides and keep mature proteins from denaturing. To meet the challenge, cardiomyocytes have developed multi-layered protein quality control (PQC) mechanisms which are carried out primarily by chaperones and ubiquitin-proteasome system mediated proteolysis. Autophagy may also participate in PQC in cardiomyocytes, especially under pathological conditions. Cardiac PQC often becomes inadequate in heart disease, which may play an important role in the development of congestive heart failure.

Original languageEnglish (US)
Pages (from-to)11-27
Number of pages17
JournalJournal of Molecular and Cellular Cardiology
Volume45
Issue number1
DOIs
StatePublished - Jul 1 2008
Externally publishedYes

Fingerprint

Cardiac Myocytes
Quality Control
Proteins
Autophagy
Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
Heart Diseases
Heart Failure
Peptides

Keywords

  • Autophagy
  • Chaperones
  • Proteases
  • Proteasome
  • Signal transduction
  • Ubiquitin

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

Protein quality control and degradation in cardiomyocytes. / Wang, Xuejun; Su, Huabo; Ranek, Mark.

In: Journal of Molecular and Cellular Cardiology, Vol. 45, No. 1, 01.07.2008, p. 11-27.

Research output: Contribution to journalReview article

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