Protein kinase CK2 phosphorylates the Nef protein from a neurovirulent simian immunodeficiency virus

Matthew J. Caples, Janice E. Clements, Sheila A. Barber

Research output: Contribution to journalArticle

Abstract

The Nef protein of Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV) is a pluripotent accessory protein that plays a critical role in disease progression. One analogous characteristic of Nef proteins from SIV and HIV is the ability to associate with cellular kinases. We have previously reported that the Nef protein from a macrophage-tropic neurovirulent SIV clone, SIV/17E-Fr, is associated with an unknown kinase activity that is distinct from the p21-associated kinase that interacts with SIVmac239 Nef. Using site-directed mutagenesis and kinase-specific inhibitors, we have identified this kinase as the ubiquitous serine/threonine kinase, protein kinase CK2.

Original languageEnglish (US)
Pages (from-to)156-164
Number of pages9
JournalVirology
Volume348
Issue number1
DOIs
StatePublished - Apr 25 2006

Keywords

  • Nef
  • Neurovirulent
  • Protein kinase CK2
  • SIV

ASJC Scopus subject areas

  • Virology

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