TY - JOUR
T1 - Protein kinase C
T2 - A new linkage marker for growth hormone and for COL1A1
AU - Summar, M. L.
AU - Phillips, J. A.
AU - Krishnamani, M. R.S.
AU - Keefer, J.
AU - Trofatter, J.
AU - Schwartz, R. C.
AU - Tsipouras, P.
AU - Willard, H.
AU - Ullrich, A.
N1 - Funding Information:
The authors thank Robert Worrell for r::;>roduction of the photographs in Fig. 1. This work is supported in part by National Institutes of Health Grants T32DK070601 (M. L. Summar), and AM01434 and AM35592 (J. A. Phillips III) and a Clinical Investigator Award (AR-01224) (P. Tsipouras).
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1989/7
Y1 - 1989/7
N2 - An expanded linkage group on the long arm of human chromosome 17 is reported. Using the CEPH panel of DNAs and restriction fragment length polymorphism (RFLP) markers for the centromere locus (D17Z1), growth hormone (GH1), collagen type I α1 (COL1A1), and protein kinase C-α polypeptide (PKCA) loci, θ̂ values of 0.03, 0.11, and 0.23 were found between PKCA and GH1, PKCA and COL1A1, and PKCA and D17Z1, respectively. The θ̂ values calculated for GH1 versus COL1A1 or D17Z1 were 0.11 and 0.23, respectively. Sex-specific recombination rates were calculated for the best likelihood order and demonstrate female recombination greater than male recombination. Therefore, the loci studied span a map region of approximately 30 cm between 17cen and 17q24, with the most likely gene order being D17Z1-COL1A1-PKCA-GH1.
AB - An expanded linkage group on the long arm of human chromosome 17 is reported. Using the CEPH panel of DNAs and restriction fragment length polymorphism (RFLP) markers for the centromere locus (D17Z1), growth hormone (GH1), collagen type I α1 (COL1A1), and protein kinase C-α polypeptide (PKCA) loci, θ̂ values of 0.03, 0.11, and 0.23 were found between PKCA and GH1, PKCA and COL1A1, and PKCA and D17Z1, respectively. The θ̂ values calculated for GH1 versus COL1A1 or D17Z1 were 0.11 and 0.23, respectively. Sex-specific recombination rates were calculated for the best likelihood order and demonstrate female recombination greater than male recombination. Therefore, the loci studied span a map region of approximately 30 cm between 17cen and 17q24, with the most likely gene order being D17Z1-COL1A1-PKCA-GH1.
UR - http://www.scopus.com/inward/record.url?scp=0024698637&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024698637&partnerID=8YFLogxK
U2 - 10.1016/0888-7543(89)90104-3
DO - 10.1016/0888-7543(89)90104-3
M3 - Article
C2 - 2570026
AN - SCOPUS:0024698637
VL - 5
SP - 163
EP - 165
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 1
ER -