Protein kinase C: A new linkage marker for growth hormone and for COL1A1

M. L. Summar, J. A. Phillips, M. R.S. Krishnamani, J. Keefer, J. Trofatter, R. C. Schwartz, P. Tsipouras, H. Willard, A. Ullrich

Research output: Contribution to journalArticlepeer-review

Abstract

An expanded linkage group on the long arm of human chromosome 17 is reported. Using the CEPH panel of DNAs and restriction fragment length polymorphism (RFLP) markers for the centromere locus (D17Z1), growth hormone (GH1), collagen type I α1 (COL1A1), and protein kinase C-α polypeptide (PKCA) loci, θ̂ values of 0.03, 0.11, and 0.23 were found between PKCA and GH1, PKCA and COL1A1, and PKCA and D17Z1, respectively. The θ̂ values calculated for GH1 versus COL1A1 or D17Z1 were 0.11 and 0.23, respectively. Sex-specific recombination rates were calculated for the best likelihood order and demonstrate female recombination greater than male recombination. Therefore, the loci studied span a map region of approximately 30 cm between 17cen and 17q24, with the most likely gene order being D17Z1-COL1A1-PKCA-GH1.

Original languageEnglish (US)
Pages (from-to)163-165
Number of pages3
JournalGenomics
Volume5
Issue number1
DOIs
StatePublished - Jul 1989
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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