Protein-kinase a and human disease: The core of cAMP-dependent signaling in health and disease

C. A. Stratakis, W. R. Miller, E. Severin, K. V. Chin, J. Bertherat, P. S. Amieux, C. Eng, G. M. Kammer, J. E. Dumont, G. Tortora, M. A. Beaven, T. T. Puck, Suzanne M Jan De Beur, L. S. Weistein, Y. S. Cho-Chung

Research output: Contribution to journalArticle

Abstract

This report summarizes several aspects of protein kinase A (PKA) signaling and its involvement in health and disease. It follows the discovery that PRKAR1A, the gene that codes for the relatively abundant regulatory subunit type 1A of protein kinase A, is the tumor suppressor gene responsible for the multiple endocrine neoplasia syndrome known as "Carney complex." Although cyclic AMP (cAMP)-dependent signaling has already been found to be involved in the pathogenesis of other genetic conditions predisposing to tumor development, this is the first time that PKA itself was directly involved in tumorigenesis and, perhaps, carcinogenesis in an inherited disease.

Original languageEnglish (US)
Pages (from-to)169-175
Number of pages7
JournalHormone and Metabolic Research
Volume34
Issue number4
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Cyclic AMP-Dependent Protein Kinases
Cyclic AMP
Protein Kinases
Health
Tumors
Carcinogenesis
Carney Complex
Genes
Multiple Endocrine Neoplasia
Genetic Association Studies
Tumor Suppressor Genes
Neoplasms

Keywords

  • Carney Complex
  • Chromosome 17
  • Endocrine Tumors
  • G-Proteins
  • Multiple Endocrine Neoplasia
  • Oncogene
  • Protein Kinase A
  • Regulatory Subunits
  • Tumor Suppressor Gene

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Stratakis, C. A., Miller, W. R., Severin, E., Chin, K. V., Bertherat, J., Amieux, P. S., ... Cho-Chung, Y. S. (2002). Protein-kinase a and human disease: The core of cAMP-dependent signaling in health and disease. Hormone and Metabolic Research, 34(4), 169-175. https://doi.org/10.1055/s-2002-26710

Protein-kinase a and human disease : The core of cAMP-dependent signaling in health and disease. / Stratakis, C. A.; Miller, W. R.; Severin, E.; Chin, K. V.; Bertherat, J.; Amieux, P. S.; Eng, C.; Kammer, G. M.; Dumont, J. E.; Tortora, G.; Beaven, M. A.; Puck, T. T.; Jan De Beur, Suzanne M; Weistein, L. S.; Cho-Chung, Y. S.

In: Hormone and Metabolic Research, Vol. 34, No. 4, 2002, p. 169-175.

Research output: Contribution to journalArticle

Stratakis, CA, Miller, WR, Severin, E, Chin, KV, Bertherat, J, Amieux, PS, Eng, C, Kammer, GM, Dumont, JE, Tortora, G, Beaven, MA, Puck, TT, Jan De Beur, SM, Weistein, LS & Cho-Chung, YS 2002, 'Protein-kinase a and human disease: The core of cAMP-dependent signaling in health and disease', Hormone and Metabolic Research, vol. 34, no. 4, pp. 169-175. https://doi.org/10.1055/s-2002-26710
Stratakis, C. A. ; Miller, W. R. ; Severin, E. ; Chin, K. V. ; Bertherat, J. ; Amieux, P. S. ; Eng, C. ; Kammer, G. M. ; Dumont, J. E. ; Tortora, G. ; Beaven, M. A. ; Puck, T. T. ; Jan De Beur, Suzanne M ; Weistein, L. S. ; Cho-Chung, Y. S. / Protein-kinase a and human disease : The core of cAMP-dependent signaling in health and disease. In: Hormone and Metabolic Research. 2002 ; Vol. 34, No. 4. pp. 169-175.
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