Protein deprivation causes reversible impairment of mucosal immune response to cholera toxoid/toxin in rat gut [12]

Wayne S. Barry, Nathaniel F. Pierce

Research output: Contribution to journalLetter

Abstract

Secretory antibodies may be the major defence against mucosal infections, especially those due to viruses and non-invasive pathogens such as Vibrio cholerae and toxinogenic Escherichia coli. The high incidence of mucosal infections in malnourished protein-deficient children1 may result from defective antibody production2, but evidence for this is conflicting3. We report here that protein deficiency markedly impairs the mucosal immune response to cholera toxoid/toxin (CT), a protein antigen, in rats and that this impairment is rapidly reversed by refeeding.

Original languageEnglish (US)
Pages (from-to)64-65
Number of pages2
JournalNature
Volume281
Issue number5726
DOIs
StatePublished - Dec 1 1979

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ASJC Scopus subject areas

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