Protein conjugates of SH3-domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases

Rakesh Tiwari, Keykavous Parang

Research output: Contribution to journalArticlepeer-review

Abstract

(Figure Presented) Double trouble: Designing bivalent inhibitors of protein kinases by using a protein (hAGT) as a spacer between SH3-domain-binding ligands and an ATP-binding-site inhibitors is described.

Original languageEnglish (US)
Pages (from-to)2445-2448
Number of pages4
JournalChemBioChem
Volume10
Issue number15
DOIs
StatePublished - Oct 12 2009
Externally publishedYes

Keywords

  • Bivalent inhibitors
  • Peptides
  • Polyproline motifs
  • Proteins
  • Tyrosine kinases

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology

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