Protein conjugates of SH3-domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases

Rakesh Tiwari; Keykavous Parang

doi:10.1002/cbic.200900462

Protein conjugates of SH3-domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases

Rakesh Tiwari, Keykavous Parang

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

(Figure Presented) Double trouble: Designing bivalent inhibitors of protein kinases by using a protein (hAGT) as a spacer between SH3-domain-binding ligands and an ATP-binding-site inhibitors is described.

Original language	English (US)
Pages (from-to)	2445-2448
Number of pages	4
Journal	ChemBioChem
Volume	10
Issue number	15
DOIs	https://doi.org/10.1002/cbic.200900462
State	Published - Oct 12 2009
Externally published	Yes

Keywords

Bivalent inhibitors
Peptides
Polyproline motifs
Proteins
Tyrosine kinases

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Molecular Medicine
Molecular Biology

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10.1002/cbic.200900462

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title = "Protein conjugates of SH3-domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases",

abstract = "(Figure Presented) Double trouble: Designing bivalent inhibitors of protein kinases by using a protein (hAGT) as a spacer between SH3-domain-binding ligands and an ATP-binding-site inhibitors is described.",

keywords = "Bivalent inhibitors, Peptides, Polyproline motifs, Proteins, Tyrosine kinases",

author = "Rakesh Tiwari and Keykavous Parang",

year = "2009",

month = oct,

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doi = "10.1002/cbic.200900462",

language = "English (US)",

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AU - Tiwari, Rakesh

AU - Parang, Keykavous

PY - 2009/10/12

Y1 - 2009/10/12

N2 - (Figure Presented) Double trouble: Designing bivalent inhibitors of protein kinases by using a protein (hAGT) as a spacer between SH3-domain-binding ligands and an ATP-binding-site inhibitors is described.

AB - (Figure Presented) Double trouble: Designing bivalent inhibitors of protein kinases by using a protein (hAGT) as a spacer between SH3-domain-binding ligands and an ATP-binding-site inhibitors is described.

KW - Bivalent inhibitors

KW - Peptides

KW - Polyproline motifs

KW - Proteins

KW - Tyrosine kinases

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DO - 10.1002/cbic.200900462

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ER -

Protein conjugates of SH3-domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases

Abstract

Keywords

ASJC Scopus subject areas

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