Protein conjugates of SH3-domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases

Rakesh Tiwari, Keykavous Parang

Research output: Contribution to journalArticle

Abstract

(Figure Presented) Double trouble: Designing bivalent inhibitors of protein kinases by using a protein (hAGT) as a spacer between SH3-domain-binding ligands and an ATP-binding-site inhibitors is described.

Original languageEnglish (US)
Pages (from-to)2445-2448
Number of pages4
JournalChemBioChem
Volume10
Issue number15
DOIs
StatePublished - Oct 12 2009
Externally publishedYes

Fingerprint

src Homology Domains
Protein Kinase Inhibitors
Adenosine Triphosphate
Binding Sites
Ligands
Proteins

Keywords

  • Bivalent inhibitors
  • Peptides
  • Polyproline motifs
  • Proteins
  • Tyrosine kinases

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology

Cite this

Protein conjugates of SH3-domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases. / Tiwari, Rakesh; Parang, Keykavous.

In: ChemBioChem, Vol. 10, No. 15, 12.10.2009, p. 2445-2448.

Research output: Contribution to journalArticle

Tiwari, Rakesh ; Parang, Keykavous. / Protein conjugates of SH3-domain ligands and ATP-competitive inhibitors as bivalent inhibitors of protein kinases. In: ChemBioChem. 2009 ; Vol. 10, No. 15. pp. 2445-2448.
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