TY - JOUR
T1 - Protein chip technology
AU - Zhu, Heng
AU - Snyder, Michael
N1 - Funding Information:
HZ is supported by a postdoctoral fellowship from the Damon Runyon-Walter Winchell Cancer Research Foundation. Research in the Snyder lab is supported by grants from the National Institutes of Health.
PY - 2003/2
Y1 - 2003/2
N2 - Microarray technology has become a crucial tool for large-scale and high-throughput biology. It allows fast, easy and parallel detection of thousands of addressable elements in a single experiment. In the past few years, protein microarray technology has shown its great potential in basic research, diagnostics and drug discovery. It has been applied to analyse antibody-antigen, protein-protein, protein-nucleic-acid, protein-lipid and protein-small-molecule interactions, as well as enzyme-substrate interactions. Recent progress in the field of protein chips includes surface chemistry, capture molecule attachment, protein labeling and detection methods, high-throughput protein/antibody production, and applications to analyse entire proteomes.
AB - Microarray technology has become a crucial tool for large-scale and high-throughput biology. It allows fast, easy and parallel detection of thousands of addressable elements in a single experiment. In the past few years, protein microarray technology has shown its great potential in basic research, diagnostics and drug discovery. It has been applied to analyse antibody-antigen, protein-protein, protein-nucleic-acid, protein-lipid and protein-small-molecule interactions, as well as enzyme-substrate interactions. Recent progress in the field of protein chips includes surface chemistry, capture molecule attachment, protein labeling and detection methods, high-throughput protein/antibody production, and applications to analyse entire proteomes.
UR - http://www.scopus.com/inward/record.url?scp=0037307131&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037307131&partnerID=8YFLogxK
U2 - 10.1016/S1367-5931(02)00005-4
DO - 10.1016/S1367-5931(02)00005-4
M3 - Review article
C2 - 12547427
AN - SCOPUS:0037307131
SN - 1367-5931
VL - 7
SP - 55
EP - 63
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 1
ER -