Protein binding of vancomycin in a patient with immunoglobulin A myeloma

T. G. Cantu, J. D. Dick, D. E. Elliott, R. L. Humphrey, D. M. Kornhauser

Research output: Contribution to journalArticlepeer-review

Abstract

Atypical vancomycin pharmacokinetics were observed in an immunoglobulin A myeloma patient. Drug concentrations in serum were extremely elevated, the elimination half-life was prolonged despite normal renal function, and the vancomycin therapy was ineffective. Extensive binding of vancomycin, presumably by high concentrations of an aberrant immunoglobulin A protein, may have accounted for these observations.

Original languageEnglish (US)
Pages (from-to)1459-1461
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume34
Issue number7
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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