TY - JOUR
T1 - Protein arrays and microarrays
AU - Zhu, Heng
AU - Snyder, Michael
N1 - Funding Information:
H Zhu is supported by the postdoctoral fellowship from the Cancer Research Fund of the Damon Runyon-Walter Winchell Foundation. The research in the Snyder laboratory is supported by grants from the National Institutes of Health and Defense Research Project Agency. We thank A Kumar, P Coelho, C Costigan, and G Michaud for their critical comments on the manuscript.
PY - 2001/2/1
Y1 - 2001/2/1
N2 - In the past, studies of protein activities have focused on studying a single protein at a time, which is often time-consuming and expensive. Recently, with the sequencing of entire genomes, large-scale proteome analysis has begun. Arrays of proteins have been used for the determination of subcellular localization, analysis of protein-protein interactions and biochemical analysis of protein function. New protein-microarray technologies have been introduced that enable the high-throughput analysis of protein activities. These have the potential to revolutionize the analysis of entire proteomes.
AB - In the past, studies of protein activities have focused on studying a single protein at a time, which is often time-consuming and expensive. Recently, with the sequencing of entire genomes, large-scale proteome analysis has begun. Arrays of proteins have been used for the determination of subcellular localization, analysis of protein-protein interactions and biochemical analysis of protein function. New protein-microarray technologies have been introduced that enable the high-throughput analysis of protein activities. These have the potential to revolutionize the analysis of entire proteomes.
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U2 - 10.1016/S1367-5931(00)00170-8
DO - 10.1016/S1367-5931(00)00170-8
M3 - Review article
C2 - 11166646
AN - SCOPUS:0035252675
SN - 1367-5931
VL - 5
SP - 40
EP - 45
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
IS - 1
ER -