Protein Array-based Approaches for Biomarker Discovery in Cancer

Yi Huang, Heng Zhu

Research output: Contribution to journalReview article

Abstract

Biomarkers are deemed to be potential tools in early diagnosis, therapeutic monitoring, and prognosis evaluation for cancer, with simplicity as well as economic advantages compared with computed tomography and biopsy. However, most of the current cancer biomarkers present insufficient sensitivity as well as specificity. Therefore, there is urgent requirement for the discovery of biomarkers for cancer. As one of the most exciting emerging technologies, protein array provides a versatile and robust platform in cancer proteomics research because it shows tremendous advantages of miniaturized features, high throughput, and sensitive detections in last decades. Here, we will present a relatively complete picture on the characteristics and advance of different types of protein arrays in application for biomarker discovery in cancer, and give the future perspectives in this area of research.

Original languageEnglish (US)
Pages (from-to)73-81
Number of pages9
JournalGenomics, Proteomics and Bioinformatics
Volume15
Issue number2
DOIs
StatePublished - Apr 1 2017

Keywords

  • Biomarker
  • Cancer
  • Early diagnosis
  • Protein array
  • Proteomics

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Computational Mathematics

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