Protein analysis on a proteomic scale

Eric Phizicky, Philippe I.H. Bastiaens, Heng Zhu, Michael Snyder, Stanley Fields

Research output: Contribution to journalReview articlepeer-review

Abstract

The long-term challenge of proteomics is enormous: to define the identities, quantities, structures and functions of complete complements of proteins, and to characterize how these properties vary in different cellular contexts. One critical step in tackling this goal is the generation of sets of clones that express a representative of each protein of a proteome in a useful format, followed by the analysis of these sets on a genome-wide basis. Such studies enable genetic, biochemical and cell biological technologies to be applied on a systematic level, leading to the assignment of biochemical activities, the construction of protein arrays, the identification of interactions, and the localization of proteins within cellular compartments.

Original languageEnglish (US)
Pages (from-to)208-215
Number of pages8
JournalNature
Volume422
Issue number6928
DOIs
StatePublished - Mar 13 2003
Externally publishedYes

ASJC Scopus subject areas

  • General

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