Protective interleukin-28B genotype affects hepatitis C virus clearance, but does not contribute to HIV-1 control in a cohort of African-American elite controllers/suppressors

Maria Salgado, Gregory D. Kirk, Andrea Cox, Alleluiah Rutebemberwa, Yvonne Higgins, Jacquie Astemborski, David L. Thomas, Chloe L. Thio, Mark S. Sulkowski, Joel N. Blankson

Research output: Contribution to journalArticle

Abstract

We tested the hypothesis that a single nucleotide polymorphism (SNP) located near the interleukin-28B gene is associated with the control of hepatitis C virus and HIV-1 replication in elite controllers/suppressors. We show here that the protective genotype is not overrepresented in elite controllers/suppressors compared with HIV-1-seronegative patients and HIV-1-infected patients with viral loads more than 10 000 copies/ml. Thus, it appears that this SNP is not associated with the elite control of HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)385-387
Number of pages3
JournalAIDS
Volume25
Issue number3
DOIs
StatePublished - Jan 28 2011

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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