Protective immunity to cytomegalovirus (CMV) retinitis in AIDS is associated with CMV-specific T cells that express interferon-γ and interleukin-2 and have a CD8+ cell early maturational phenotype

Elizabeth Sinclair, Xuan Tan Qi, Margaret Sharp, Valerie Girling, Chungkee Poon, Mark Van Natta, Douglas A. Jabs, Margaret Inokuma, Holden T. Maecker, Barry Bredt, Mark A. Jacobson

Research output: Contribution to journalArticle

Abstract

To determine potential correlates of immune recovery from AIDS-related cytomegalovirus retinitis (CMVR), multiparameter flow cytometry was used to characterize CMV-specific T cells from subjects with CMVR. Individuals with active retinitis were compared with those who had been clinically immunorestored by antiretroviral therapy and had ≥2 years of ophthalmologic follow-up without anti-CMV therapy or retinitis reactivation or progression. In comparison with patients with active retinitis, immunorestored patients had higher circulating CD4+ and CD8+ T cells expressing interleukin-2 and interferon-γ in response to combined CMV pp65 and IE1 peptide pool stimulation. CD4+ T cell responses were predominantly to pp65, whereas CD8+ T cell responses were predominantly to IE. Immunorestored patients, compared with patients with active retinitis, had increased levels of circulating CMV-specific CD8+ T cells with "early" (CD27+CD28+CD45RA+, CD27 +CD28+CD45RA-) and "intermediate" (CD27-CD28+CD45RA-) phenotypes. Recovery from AIDS-related CMVR after the initiation of antiretroviral therapy may be mediated by CMV-specific CD4+ and CD8+ T cells capable of promoting antigen-specific CD8+ T cell proliferation.

Original languageEnglish (US)
Pages (from-to)1537-1546
Number of pages10
JournalJournal of Infectious Diseases
Volume194
Issue number11
DOIs
StatePublished - Dec 1 2006

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Protective immunity to cytomegalovirus (CMV) retinitis in AIDS is associated with CMV-specific T cells that express interferon-γ and interleukin-2 and have a CD8<sup>+</sup> cell early maturational phenotype'. Together they form a unique fingerprint.

  • Cite this