Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis

Daniel T. Claiborne, Eileen Scully, Christine D. Palmer, Jessica L. Prince, Gladys N. Macharia, Jakub Kopycinski, Clive M. Michelo, Howard W. Wiener, Rachel Parker, Krystelle Nganou-Makamdop, Daniel Douek, Marcus Altfeld, Jill Gilmour, Matt A. Price, Jianming Tang, William Kilembe, Susan A. Allen, Eric Hunter

Research output: Contribution to journalArticle

Abstract

Despite extensive research on the mechanisms of HLA-mediated immune control of HIV-1 pathogenesis, it is clear that much remains to be discovered, as exemplified by protective HLA alleles like HLA-B*81 which are associated with profound protection from CD4+ T cell decline without robust control of early plasma viremia. Here, we report on additional HLA class I (B*1401, B*57, B*5801, as well as B*81), and HLA class II (DQB1*02 and DRB1*15) alleles that display discordant virological and immunological phenotypes in a Zambian early infection cohort. HLA class I alleles of this nature were also associated with enhanced immune responses to conserved epitopes in Gag. Furthermore, these HLA class I alleles were associated with reduced levels of lipopolysaccharide (LPS) in the plasma during acute infection. Elevated LPS levels measured early in infection predicted accelerated CD4+ T cell decline, as well as immune activation and exhaustion. Taken together, these data suggest novel mechanisms for HLA-mediated immune control of HIV-1 pathogenesis that do not necessarily involve significant control of early viremia and point to microbial translocation as a direct driver of HIV-1 pathogenesis rather than simply a consequence.

Original languageEnglish (US)
Pages (from-to)e1007981
JournalPLoS pathogens
Volume15
Issue number8
DOIs
StatePublished - Aug 1 2019

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HIV Infections
Lipopolysaccharides
Alleles
HIV-1
Viremia
Infection
T-Lymphocytes
HLA-B Antigens
Epitopes
Phenotype
Research

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Molecular Biology
  • Genetics
  • Virology

Cite this

Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis. / Claiborne, Daniel T.; Scully, Eileen; Palmer, Christine D.; Prince, Jessica L.; Macharia, Gladys N.; Kopycinski, Jakub; Michelo, Clive M.; Wiener, Howard W.; Parker, Rachel; Nganou-Makamdop, Krystelle; Douek, Daniel; Altfeld, Marcus; Gilmour, Jill; Price, Matt A.; Tang, Jianming; Kilembe, William; Allen, Susan A.; Hunter, Eric.

In: PLoS pathogens, Vol. 15, No. 8, 01.08.2019, p. e1007981.

Research output: Contribution to journalArticle

Claiborne, DT, Scully, E, Palmer, CD, Prince, JL, Macharia, GN, Kopycinski, J, Michelo, CM, Wiener, HW, Parker, R, Nganou-Makamdop, K, Douek, D, Altfeld, M, Gilmour, J, Price, MA, Tang, J, Kilembe, W, Allen, SA & Hunter, E 2019, 'Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis', PLoS pathogens, vol. 15, no. 8, pp. e1007981. https://doi.org/10.1371/journal.ppat.1007981
Claiborne, Daniel T. ; Scully, Eileen ; Palmer, Christine D. ; Prince, Jessica L. ; Macharia, Gladys N. ; Kopycinski, Jakub ; Michelo, Clive M. ; Wiener, Howard W. ; Parker, Rachel ; Nganou-Makamdop, Krystelle ; Douek, Daniel ; Altfeld, Marcus ; Gilmour, Jill ; Price, Matt A. ; Tang, Jianming ; Kilembe, William ; Allen, Susan A. ; Hunter, Eric. / Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis. In: PLoS pathogens. 2019 ; Vol. 15, No. 8. pp. e1007981.
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