Protective effect of N-acetylcysteine in isoniazid induced hepatic injury in growing rats

S. Attri, S. V. Rana, K. Vaiphie, R. Katyal, C. P. Sodhi, S. Kanwar, K. Singh

Research output: Contribution to journalArticlepeer-review


Status of oxidative/antioxidative profile was the mechanistic approach to inumerate the nature of protection by N-acetylcysteine (NAC) in isoniazid (INH) exposed experimental animals. Analysis of lipid peroxidation, thiol levels, cytochrome P450, superoxide dismutase (SOD), catalase, glutathione peroxidase, reductase and transferase were estimated in liver along with the body and liver weight of animals and histological observations. Isoniazid exposure to animals resulted in no change in body and liver weights. Thiols, lipid peroxidation, catalase, SOD glutathione peroxidase, reductase, transferase and cytochrome P450 levels were altered with INH exposure. Supplementation of NAC with INH protected the animals against hepatotoxic reactions by minimizing the free radical induced tissue injury and overall maintenance of the endogenous scavengers of free radicals.

Original languageEnglish (US)
Pages (from-to)436-440
Number of pages5
JournalIndian journal of experimental biology
Issue number5
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology
  • Cell Biology


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