Protective effect of erythropoietin in neonatal hypoxic ischemia in mice

Hiroko Matsushita; Michael V. Johnston; Mary S. Lange; Mary Ann Wilson

doi:10.1097/00001756-200309150-00020

Protective effect of erythropoietin in neonatal hypoxic ischemia in mice

Hiroko Matsushita, Michael V. Johnston, Mary S. Lange, Mary Ann Wilson

Kennedy Krieger Institute

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NRκB- immunoreactive neurons were observed in the injured areas; these areas were smaller in the erythropoietin group. To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice.

Original language	English (US)
Pages (from-to)	1757-1761
Number of pages	5
Journal	Neuroreport
Volume	14
Issue number	13
DOIs	https://doi.org/10.1097/00001756-200309150-00020
State	Published - Sep 15 2003

Keywords

Caspase-3
NFκB
Neuroprotection

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-200309150-00020

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abstract = "The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NRκB- immunoreactive neurons were observed in the injured areas; these areas were smaller in the erythropoietin group. To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice.",

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AU - Matsushita, Hiroko

AU - Johnston, Michael V.

AU - Lange, Mary S.

AU - Wilson, Mary Ann

PY - 2003/9/15

Y1 - 2003/9/15

N2 - The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NRκB- immunoreactive neurons were observed in the injured areas; these areas were smaller in the erythropoietin group. To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice.

AB - The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NRκB- immunoreactive neurons were observed in the injured areas; these areas were smaller in the erythropoietin group. To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice.

KW - Caspase-3

KW - NFκB

KW - Neuroprotection

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JO - NeuroReport

JF - NeuroReport

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ER -

Protective effect of erythropoietin in neonatal hypoxic ischemia in mice

Abstract

Keywords

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