Protective effect of erythropoietin in neonatal hypoxic ischemia in mice

Hiroko Matsushita, Michael V. Johnston, Mary S. Lange, Mary Ann Wilson

Research output: Contribution to journalArticlepeer-review


The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NRκB- immunoreactive neurons were observed in the injured areas; these areas were smaller in the erythropoietin group. To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice.

Original languageEnglish (US)
Pages (from-to)1757-1761
Number of pages5
Issue number13
StatePublished - Sep 15 2003


  • Caspase-3
  • NFκB
  • Neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)


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