Protective effect of erythropoietin in neonatal hypoxic ischemia in mice

Hiroko Matsushita, Michael V. Johnston, Mary S. Lange, Mary Ann Wilson

Research output: Contribution to journalArticle

Abstract

The effect of systemic erythropoietin pretreatment on hypoxic ischemic injury was examined in neonatal mice. Injury was significantly less in cortex, hippocampus, striatum and thalamus of erythropoietin-treated animals (5 U/g vs vehicle) 24 h after hypoxic ischemia and in all of these regions except hippocampus at 7 days. Activated caspase-3- and activated NRκB- immunoreactive neurons were observed in the injured areas; these areas were smaller in the erythropoietin group. To our knowledge, this is the first report demonstrating persistent neuroprotective effects of erythropoietin in neonatal mice.

Original languageEnglish (US)
Pages (from-to)1757-1761
Number of pages5
JournalNeuroreport
Volume14
Issue number13
DOIs
StatePublished - Sep 15 2003

Keywords

  • Caspase-3
  • NFκB
  • Neuroprotection

ASJC Scopus subject areas

  • Neuroscience(all)

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