Protective effect of diazepam pretreatment on soman-induced brain lesion formation

Lee J. Martin, Jeffrey A. Doebler, Tsung Ming Shih, Adam Anthony

Research output: Contribution to journalArticlepeer-review

Abstract

Histopathological analyses of brains of rats receiving a single 0.9 LD50 injection of soman, a potent anticholinesterase neurotoxin, revealed massive widespread lesions in the cerebral cortex and thalamus 4 weeks post-injection. Such lesions were not evidenced in rats receiving diazepam (2.2 mg/kg, i.m.) 10 min prior to soman treatment. Thus, anticonvulsant antidotes may aid in preventing extensive or permanent brain damage in rats surviving near-lethal soman dosages.

Original languageEnglish (US)
Pages (from-to)287-289
Number of pages3
JournalBrain research
Volume325
Issue number1-2
DOIs
StatePublished - Jan 28 1985
Externally publishedYes

Keywords

  • cerebrocortical lesions
  • diazepam
  • neuropathology
  • neurotoxicity
  • soman
  • thalamic lesions

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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