Protective CD8+ T cells induced by malaria sporozoites do not undergo modulation of interleukin-7 receptor expression

Alexandre Morrot, Ian A. Cockburn, Michael Overstreet, Dolores Rodríguez, Fidel Zavala

Research output: Contribution to journalArticlepeer-review

Abstract

CD8+ T cells induced by Plasmodium yoelii sporozoites develop into protective memory cells without undergoing changes in interleukin-7 receptor α (IL-7Rα) expression, differing from the development of memory CD8+ T cells against viruses, which is associated with enhanced IL-7Rα expression. This suggests a microbe-dependent diversity in the signals determining the development of memory populations.

Original languageEnglish (US)
Pages (from-to)2495-2497
Number of pages3
JournalInfection and immunity
Volume74
Issue number4
DOIs
StatePublished - Apr 2006

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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