Protective anti-sporozoite antibodies induced by a chemically defined synthetic vaccine

Fidel P Zavala, Sylvia Chai

Research output: Contribution to journalArticle

Abstract

Chemically defined synthetic polymers, known as multiple antigen peptide systems (MAPs) represent an effective and novel approach for engineering peptide-based vaccines. Ten different mono and di-epitope MAP models, containing different arrangements and stoichiometry of functional B and/or T helper epitopes from the circumsporozoite protein of Plasmodium berghei were used to immunize mice. High titers of antibody and protective immunity against sporozoite challenge were elicited by MAPs containing T and B epitopes arranged in tandem and in equimolar amounts. These results indicate that MAPs may serve as a basis for developing subunit vaccines to induce high levels of antibodies against sporozoites.

Original languageEnglish (US)
Pages (from-to)271-274
Number of pages4
JournalImmunology Letters
Volume25
Issue number1-3
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Sporozoites
Synthetic Vaccines
Epitopes
Anti-Idiotypic Antibodies
Subunit Vaccines
Plasmodium berghei
Antibodies
Immunity
Polymers
Antigens
Peptides
Proteins

Keywords

  • Helper epitope
  • Plasmodium berghei
  • Sporozoite
  • Synthetic peptide
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Protective anti-sporozoite antibodies induced by a chemically defined synthetic vaccine. / Zavala, Fidel P; Chai, Sylvia.

In: Immunology Letters, Vol. 25, No. 1-3, 1990, p. 271-274.

Research output: Contribution to journalArticle

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