Abstract
Chemically defined synthetic polymers, known as multiple antigen peptide systems (MAPs) represent an effective and novel approach for engineering peptide-based vaccines. Ten different mono and di-epitope MAP models, containing different arrangements and stoichiometry of functional B and/or T helper epitopes from the circumsporozoite protein of Plasmodium berghei were used to immunize mice. High titers of antibody and protective immunity against sporozoite challenge were elicited by MAPs containing T and B epitopes arranged in tandem and in equimolar amounts. These results indicate that MAPs may serve as a basis for developing subunit vaccines to induce high levels of antibodies against sporozoites.
Original language | English (US) |
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Pages (from-to) | 271-274 |
Number of pages | 4 |
Journal | Immunology Letters |
Volume | 25 |
Issue number | 1-3 |
DOIs | |
State | Published - Aug 1990 |
Externally published | Yes |
Keywords
- Helper epitope
- Plasmodium berghei
- Sporozoite
- Synthetic peptide
- Vaccine
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology