Protective anti-sporozoite antibodies induced by a chemically defined synthetic vaccine

Fidel Zavala, Sylvia Chai

Research output: Contribution to journalArticlepeer-review

Abstract

Chemically defined synthetic polymers, known as multiple antigen peptide systems (MAPs) represent an effective and novel approach for engineering peptide-based vaccines. Ten different mono and di-epitope MAP models, containing different arrangements and stoichiometry of functional B and/or T helper epitopes from the circumsporozoite protein of Plasmodium berghei were used to immunize mice. High titers of antibody and protective immunity against sporozoite challenge were elicited by MAPs containing T and B epitopes arranged in tandem and in equimolar amounts. These results indicate that MAPs may serve as a basis for developing subunit vaccines to induce high levels of antibodies against sporozoites.

Original languageEnglish (US)
Pages (from-to)271-274
Number of pages4
JournalImmunology Letters
Volume25
Issue number1-3
DOIs
StatePublished - Aug 1990
Externally publishedYes

Keywords

  • Helper epitope
  • Plasmodium berghei
  • Sporozoite
  • Synthetic peptide
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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