Protective action by thiouracil against the acute toxicity in mice of O-ethyl O-(4-nitrophenyl) phenylphosphonothioate (EPN)

Michael H. Kelemen, Robert L. Volle

Research output: Contribution to journalArticle

Abstract

Pretreatment with thiouracil provided significant protection to mice treated subsequently with the organophosphorus insecticide EPN. Uracil did not share the protective properties of thiouracil. Although other mechanisms are possible, the protective action of thiouracil is explained best by the working hypothesis that the oxidative desulfuration of thiouracil to form uracil interferes with a similar desulfuration of EPN and the formation of its pharmacologically active oxygen reaction product. Thiouracil also afforded some protection to mice against the acute toxicity of parathion. On the other hand, it had no protective action against the acute toxicity of the irreversible anticholinesterase compound, 217 AO. Treatment of mice with the metabolic inhibitor SKF 525A enhanced the lethal actions of EPN.

Original languageEnglish (US)
Pages (from-to)418-424
Number of pages7
JournalToxicology and Applied Pharmacology
Volume7
Issue number3
DOIs
StatePublished - May 1965
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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