Protection of exendin-4 analog on ERG and Ops in experimental diabetic rats

Yu Zhang, Jing Fa Zhang, Xia Lei, Guo Tong Xu, Wen Ye

Research output: Contribution to journalArticlepeer-review

Abstract

• Aim: To observe the effect of exendin-4 analog on blood glucose in diabetic rats induced by streptozotocin (STZ) and the influence on their electroretinogram (ERG). • Methods: Thirty-six rats were included in the experiment. The rats were divided into 3 groups: normal control (N, n=8), diabetic control (D, n=8) and E4a-treated group (E4a, n=20). For E4a group, the rats were treated with E4a S. C. (0.05ug/g BW/d). For N and D groups, the rats were treated with normal saline (NS). S. C. Blood glucose levels and body weight was measured weekly. ERGs were recorded 1 and 3 months after injection. • Results: The difference of blood glucose in diabetic rats between the groups with E4a treated and the normal control was of no significance (6.68 ± 0.37 vs 6.95 ± 0.41 mmol/L, P > 0.05). The blood glucose of E4a group was much lower than that of D group. The amplitude of b-wave and oscillatory potentials (OPs) showed decrease with the progress of diabetes. The decrease in E4a treated group was less than that in untreated ones and had statistical significance (P < 0.05). • Conclusion: E4a can normalize the blood glucose of diabetic rats. Diabetes leads to the progressive decreases in the amplitudes of b-wave and OPs. E4a can reverse them nearly to their normal condition.

Original languageEnglish (US)
Pages (from-to)1573-1575
Number of pages3
JournalInternational Journal of Ophthalmology
Volume8
Issue number8
StatePublished - Aug 25 2008

Keywords

  • Diabetic retinopathy
  • Electroretinogram
  • Exendin-4 analog
  • High glucose

ASJC Scopus subject areas

  • Ophthalmology

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