Abstract
• Aim: To observe the effect of exendin-4 analog on blood glucose in diabetic rats induced by streptozotocin (STZ) and the influence on their electroretinogram (ERG). • Methods: Thirty-six rats were included in the experiment. The rats were divided into 3 groups: normal control (N, n=8), diabetic control (D, n=8) and E4a-treated group (E4a, n=20). For E4a group, the rats were treated with E4a S. C. (0.05ug/g BW/d). For N and D groups, the rats were treated with normal saline (NS). S. C. Blood glucose levels and body weight was measured weekly. ERGs were recorded 1 and 3 months after injection. • Results: The difference of blood glucose in diabetic rats between the groups with E4a treated and the normal control was of no significance (6.68 ± 0.37 vs 6.95 ± 0.41 mmol/L, P > 0.05). The blood glucose of E4a group was much lower than that of D group. The amplitude of b-wave and oscillatory potentials (OPs) showed decrease with the progress of diabetes. The decrease in E4a treated group was less than that in untreated ones and had statistical significance (P < 0.05). • Conclusion: E4a can normalize the blood glucose of diabetic rats. Diabetes leads to the progressive decreases in the amplitudes of b-wave and OPs. E4a can reverse them nearly to their normal condition.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1573-1575 |
| Number of pages | 3 |
| Journal | International Journal of Ophthalmology |
| Volume | 8 |
| Issue number | 8 |
| State | Published - Aug 25 2008 |
| Externally published | Yes |
Keywords
- Diabetic retinopathy
- Electroretinogram
- Exendin-4 analog
- High glucose
ASJC Scopus subject areas
- Ophthalmology