Protection conferred by neonatal rotavirus infection against subsequent rotavirus diarrhea

M. K. Bhan, Judy F. Lew, Sunil Sazawal, Bimal K. Das, Jon R. Gentsch, Roger I. Glass

Research output: Contribution to journalArticle

Abstract

A cohort of newborns in New Delhi who were nosocomially infected with rotavirus during their first days of life were followed twice weekly for 14-23 months to determine whether neonatal infection protected them against subsequent episodes of rotavirus diarrhea. Infection occurred in 60% by the fourth day of life, was asymptomatic, and was caused predominantly by an unusual rotavirus strain (G9 P11) not previously identified in humans. The 148 children with neonatal rotavirus infection had 46% fewer attacks of rotavirus diarrhea in the follow-up period than the 56 infants without nosocomial infection (0.23 vs. 0.42 episodes/child-year, P <.05). This protection was concentrated among infants in their first year of life and was not associated with a significant decrease in disease severity. Consideration of this strain as a vaccine candidate will require further assessment of its natural protection under field conditions.

Original languageEnglish (US)
Pages (from-to)282-287
Number of pages6
JournalJournal of Infectious Diseases
Volume168
Issue number2
StatePublished - Aug 1993
Externally publishedYes

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Rotavirus Infections
Rotavirus
Diarrhea
Cross Infection
Infection
Vaccines
Newborn Infant

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Bhan, M. K., Lew, J. F., Sazawal, S., Das, B. K., Gentsch, J. R., & Glass, R. I. (1993). Protection conferred by neonatal rotavirus infection against subsequent rotavirus diarrhea. Journal of Infectious Diseases, 168(2), 282-287.

Protection conferred by neonatal rotavirus infection against subsequent rotavirus diarrhea. / Bhan, M. K.; Lew, Judy F.; Sazawal, Sunil; Das, Bimal K.; Gentsch, Jon R.; Glass, Roger I.

In: Journal of Infectious Diseases, Vol. 168, No. 2, 08.1993, p. 282-287.

Research output: Contribution to journalArticle

Bhan, MK, Lew, JF, Sazawal, S, Das, BK, Gentsch, JR & Glass, RI 1993, 'Protection conferred by neonatal rotavirus infection against subsequent rotavirus diarrhea', Journal of Infectious Diseases, vol. 168, no. 2, pp. 282-287.
Bhan MK, Lew JF, Sazawal S, Das BK, Gentsch JR, Glass RI. Protection conferred by neonatal rotavirus infection against subsequent rotavirus diarrhea. Journal of Infectious Diseases. 1993 Aug;168(2):282-287.
Bhan, M. K. ; Lew, Judy F. ; Sazawal, Sunil ; Das, Bimal K. ; Gentsch, Jon R. ; Glass, Roger I. / Protection conferred by neonatal rotavirus infection against subsequent rotavirus diarrhea. In: Journal of Infectious Diseases. 1993 ; Vol. 168, No. 2. pp. 282-287.
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