Protection against neonatal rotavirus infection by breast milk antibodies and trypsin inhibitors

S. Jayashree, M. K. Bhan, R. Kumar, N. Bhandari, S. Sazawal

Research output: Contribution to journalArticle

Abstract

The role of breast milk antirotavirus immunoglobulin A (IgA) and trypsin inhibitors in limiting the acquisition of rotavirus infection during the initial 5 days of life was evaluated among 42 exclusively breast-fed hospital-born infants, 22 of whom experienced rotavirus infection. The mean concentrations of antirotavirus IgA (ELISA Units) in the breast milk of mothers of the 22 rotavirus-infected neonates was 130.4 ± 46.4; the corresponding value in 20 noninfected neonates was 384.3 ± 328.3 (P <0.001). Similarly, the trypsin inhibitory capacity (μmols/mt/ml) of breast milk in the rotavirus-infected group was significantly lower (0.109 ± 0.095) than that in the noninfected group (0.376 ± 0.191; P <0.001). The trypsin inhibitory capacity of milk showed an inverse correlation with infant stool tryptic activity (P <0.01). Our results indicate that the acquisition of rotavirus infection during the early neonatal period depends on the concentrations of antirotavirus IgA and trypsin inhibitors in human milk and that protection is mediated by high levels of these antiviral factors.

Original languageEnglish (US)
Pages (from-to)333-338
Number of pages6
JournalJournal of Medical Virology
Volume26
Issue number3
StatePublished - 1988
Externally publishedYes

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Rotavirus Infections
Trypsin Inhibitors
Human Milk
Immunoglobulin A
Antibodies
Rotavirus
Trypsin
Newborn Infant
Antiviral Agents
Milk
Breast
Enzyme-Linked Immunosorbent Assay
Mothers

ASJC Scopus subject areas

  • Virology

Cite this

Jayashree, S., Bhan, M. K., Kumar, R., Bhandari, N., & Sazawal, S. (1988). Protection against neonatal rotavirus infection by breast milk antibodies and trypsin inhibitors. Journal of Medical Virology, 26(3), 333-338.

Protection against neonatal rotavirus infection by breast milk antibodies and trypsin inhibitors. / Jayashree, S.; Bhan, M. K.; Kumar, R.; Bhandari, N.; Sazawal, S.

In: Journal of Medical Virology, Vol. 26, No. 3, 1988, p. 333-338.

Research output: Contribution to journalArticle

Jayashree, S, Bhan, MK, Kumar, R, Bhandari, N & Sazawal, S 1988, 'Protection against neonatal rotavirus infection by breast milk antibodies and trypsin inhibitors', Journal of Medical Virology, vol. 26, no. 3, pp. 333-338.
Jayashree, S. ; Bhan, M. K. ; Kumar, R. ; Bhandari, N. ; Sazawal, S. / Protection against neonatal rotavirus infection by breast milk antibodies and trypsin inhibitors. In: Journal of Medical Virology. 1988 ; Vol. 26, No. 3. pp. 333-338.
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