Protection against cancer by plant phenylpropenoids: induction of mammalian anticarcinogenic enzymes.

A. T. Dinkova-Kostova

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Chemoprotection has established itself as a "major arm" in the "war against cancer" and induction of phase 2 detoxification enzymes as an effective strategy. Prominent among inducers are Michael reaction acceptors. Such functionalities are intrinsic to many phenylpropanoids present in edible plants, where they play roles in plant defense. This minireview focuses on the ability of such plant metabolites to elevate phase 2 enzymes in various cell culture and animal models and ultimately to protect against carcinogenesis.

Original languageEnglish (US)
Pages (from-to)595-610
Number of pages16
JournalMini reviews in medicinal chemistry
Volume2
Issue number6
StatePublished - Dec 2002

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

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