Three protecting groups useful in syntheses involving nucleosides are described. These are β-benzoyl propionyl and benzoylformyl for OH groups of nucleosides and isobutyloxycarbonyl for NH2 of the cytosine ring. The preparation and properties of 3ʹ-O- and 5ʹ-O-(β-benzoylpropionyl)thymidine, 3ʹ-O-benzoylformylthymi-dine, and N5-isobutyloxycarbonyl-3ʹ-O-β-benzoylpropionyl)deoxycytidine are described.
ASJC Scopus subject areas
- Colloid and Surface Chemistry