Protecting Groups for Nucleosides Used in Synthesizing Oligonucleotides

Robert L. Letsinger, Paul S. Miller

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Three protecting groups useful in syntheses involving nucleosides are described. These are β-benzoyl propionyl and benzoylformyl for OH groups of nucleosides and isobutyloxycarbonyl for NH2 of the cytosine ring. The preparation and properties of 3ʹ-O- and 5ʹ-O-(β-benzoylpropionyl)thymidine, 3ʹ-O-benzoylformylthymi-dine, and N5-isobutyloxycarbonyl-3ʹ-O-β-benzoylpropionyl)deoxycytidine are described.

Original languageEnglish (US)
Pages (from-to)3356-3359
Number of pages4
JournalJournal of the American Chemical Society
Issue number12
StatePublished - Jun 1969

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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