Protecting groups for nucleosides used in synthesizing oligonucleotides

Robert L. Letsinger, Paul S. Miller

Research output: Contribution to journal › Article

Abstract

Three protecting groups useful in syntheses involving nucleosides are described. These are β-benzoylpropionyl and benzoylformyl for OH groups of nucleosides and isobutyloxycarbonyl for NH2 of the cytosine ring. The preparation and properties of 3′-O- and 5′-O-(β-benzoylpropionyl)thymidine, 3′-O-benzoylformylthymidine, and N 6-isobutyloxycarbonyl-3′-O-(β-benzoylpropionyl) deoxycytidine are described.

Original languageEnglish (US)
Pages (from-to)3356-3359
Number of pages4
JournalJournal of the American Chemical Society
Volume91
Issue number12
StatePublished - 1969
Externally publishedYes

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Oligonucleotides
Nucleosides
Deoxycytidine
Cytosine
Thymidine

ASJC Scopus subject areas

  • Chemistry(all)

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Protecting groups for nucleosides used in synthesizing oligonucleotides. / Letsinger, Robert L.; Miller, Paul S.

In: Journal of the American Chemical Society, Vol. 91, No. 12, 1969, p. 3356-3359.

Research output: Contribution to journal › Article

Letsinger, RL & Miller, PS 1969, 'Protecting groups for nucleosides used in synthesizing oligonucleotides', Journal of the American Chemical Society, vol. 91, no. 12, pp. 3356-3359.
Letsinger RL, Miller PS. Protecting groups for nucleosides used in synthesizing oligonucleotides. Journal of the American Chemical Society. 1969;91(12):3356-3359.
Letsinger, Robert L. ; Miller, Paul S. / Protecting groups for nucleosides used in synthesizing oligonucleotides. In: Journal of the American Chemical Society. 1969 ; Vol. 91, No. 12. pp. 3356-3359.
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