Proteases and Protease Inhibitors

Martin Charron, William W Wright

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

This chapter discusses the potential functions of proteases and protease inhibitors within the seminiferous epithelium. Proteolysis is one of several important posttranslational modifications that a protein can undergo during its lifetime. Proteolysis is the consequence of the opposing actions of proteases and their complementary inhibitors. Ubiquitously expressed in all biological tissues and fluids, proteases are enzymes capable of catalytically cleaving peptide bonds in proteins. Because of their enzymatic activities, proteases play major roles in the differentiation and function of all cells and tissues, and they can have a profound effect on the interactions of cells with their immediate microenvironments. These enzymes are essential for the remodeling or degradation of basement membranes, and consequently, the movement of cells within an epithelium. Specific proteases can also modify cell-substrate and cell-cell interactions by degrading or activating cell adhesion molecules, procytokines, and cell surface receptors. A protease often acts in cooperation with a network of other proteins, including their complementary inhibitors. © 2005

Original languageEnglish (US)
Title of host publicationSertoli Cell Biology
PublisherElsevier Inc.
Pages121-152
Number of pages32
ISBN (Print)9780126477511
DOIs
StatePublished - 2005

Fingerprint

Protease Inhibitors
Peptide Hydrolases
Proteolysis
Cell Communication
Tissue
Seminiferous Epithelium
Proteins
Cell Adhesion Molecules
Cell Surface Receptors
Enzymes
Post Translational Protein Processing
Basement Membrane
Cell Movement
Epithelium
Degradation
Peptides
Fluids
Substrates

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Charron, M., & Wright, W. W. (2005). Proteases and Protease Inhibitors. In Sertoli Cell Biology (pp. 121-152). Elsevier Inc.. https://doi.org/10.1016/B978-012647751-1/50010-6

Proteases and Protease Inhibitors. / Charron, Martin; Wright, William W.

Sertoli Cell Biology. Elsevier Inc., 2005. p. 121-152.

Research output: Chapter in Book/Report/Conference proceedingChapter

Charron, M & Wright, WW 2005, Proteases and Protease Inhibitors. in Sertoli Cell Biology. Elsevier Inc., pp. 121-152. https://doi.org/10.1016/B978-012647751-1/50010-6
Charron M, Wright WW. Proteases and Protease Inhibitors. In Sertoli Cell Biology. Elsevier Inc. 2005. p. 121-152 https://doi.org/10.1016/B978-012647751-1/50010-6
Charron, Martin ; Wright, William W. / Proteases and Protease Inhibitors. Sertoli Cell Biology. Elsevier Inc., 2005. pp. 121-152
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