Protease-activated drug development

Ki Young Choi; Magdalena Swierczewska; Seulki Lee; Xiaoyuan Chen

doi:10.7150/thno.4068

Protease-activated drug development

Ki Young Choi, Magdalena Swierczewska, Seulki Lee, Xiaoyuan Chen

Research output: Contribution to journal › Review article › peer-review

165 Scopus citations

Abstract

In this extensive review, we elucidate the importance of proteases and their role in drug development in various diseases with an emphasis on cancer. First, key proteases are introduced along with their function in disease progression. Next, we link these proteases as targets for the development of prodrugs and provide clinical examples of protease-activatable prodrugs. Finally, we provide significant design considerations needed for the development of the next generation protease-targeted and protease-activatable prodrugs.

Original language	English (US)
Pages (from-to)	156-179
Number of pages	24
Journal	Theranostics
Volume	2
Issue number	2
DOIs	https://doi.org/10.7150/thno.4068
State	Published - 2012
Externally published	Yes

Keywords

Activatable probe
Alzheimer's disease
Aspartyl protease
Cancer
Caspase
Cathepsin
Kallikrein
MMP
PSA
Protease
Serine protease

ASJC Scopus subject areas

Medicine (miscellaneous)
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Access to Document

10.7150/thno.4068

Cite this

@article{811a030b744e477495bf5544e723af07,

title = "Protease-activated drug development",

abstract = "In this extensive review, we elucidate the importance of proteases and their role in drug development in various diseases with an emphasis on cancer. First, key proteases are introduced along with their function in disease progression. Next, we link these proteases as targets for the development of prodrugs and provide clinical examples of protease-activatable prodrugs. Finally, we provide significant design considerations needed for the development of the next generation protease-targeted and protease-activatable prodrugs.",

keywords = "Activatable probe, Alzheimer's disease, Aspartyl protease, Cancer, Caspase, Cathepsin, Kallikrein, MMP, PSA, Protease, Serine protease",

author = "Choi, {Ki Young} and Magdalena Swierczewska and Seulki Lee and Xiaoyuan Chen",

year = "2012",

doi = "10.7150/thno.4068",

language = "English (US)",

volume = "2",

pages = "156--179",

journal = "Theranostics",

issn = "1838-7640",

publisher = "Ivyspring International Publisher",

number = "2",

}

TY - JOUR

T1 - Protease-activated drug development

AU - Choi, Ki Young

AU - Swierczewska, Magdalena

AU - Lee, Seulki

AU - Chen, Xiaoyuan

PY - 2012

Y1 - 2012

N2 - In this extensive review, we elucidate the importance of proteases and their role in drug development in various diseases with an emphasis on cancer. First, key proteases are introduced along with their function in disease progression. Next, we link these proteases as targets for the development of prodrugs and provide clinical examples of protease-activatable prodrugs. Finally, we provide significant design considerations needed for the development of the next generation protease-targeted and protease-activatable prodrugs.

AB - In this extensive review, we elucidate the importance of proteases and their role in drug development in various diseases with an emphasis on cancer. First, key proteases are introduced along with their function in disease progression. Next, we link these proteases as targets for the development of prodrugs and provide clinical examples of protease-activatable prodrugs. Finally, we provide significant design considerations needed for the development of the next generation protease-targeted and protease-activatable prodrugs.

KW - Activatable probe

KW - Alzheimer's disease

KW - Aspartyl protease

KW - Cancer

KW - Caspase

KW - Cathepsin

KW - Kallikrein

KW - MMP

KW - PSA

KW - Protease

KW - Serine protease

UR - http://www.scopus.com/inward/record.url?scp=84864572139&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864572139&partnerID=8YFLogxK

U2 - 10.7150/thno.4068

DO - 10.7150/thno.4068

M3 - Review article

C2 - 22400063

AN - SCOPUS:84864572139

SN - 1838-7640

VL - 2

SP - 156

EP - 179

JO - Theranostics

JF - Theranostics

IS - 2

ER -

Protease-activated drug development

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this