Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue

Caitlin M. Guenther; Mitchell J. Brun; Antonette D. Bennett; Michelle L. Ho; Weitong Chen; Banghe Zhu; Michael Lam; Momona Yamagami; Sunkuk Kwon; Nilakshee Bhattacharya; Duncan Sousa; Annicka C. Evans; Julie Voss; Eva M. Sevick-Muraca; Mavis Agbandje-McKenna; Junghae Suh

doi:10.1016/j.ymthe.2019.01.015

Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue

Caitlin M. Guenther, Mitchell J. Brun, Antonette D. Bennett, Michelle L. Ho, Weitong Chen, Banghe Zhu, Michael Lam, Momona Yamagami, Sunkuk Kwon, Nilakshee Bhattacharya, Duncan Sousa, Annicka C. Evans, Julie Voss, Eva M. Sevick-Muraca, Mavis Agbandje-McKenna, Junghae Suh

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Guenther et al. have developed a protease-activatable AAV provector to target diseased tissue microenvironments exhibiting elevated extracellular protease activity. The provector delivers transgenes to high-MMP-activity regions of the damaged heart following a myocardial infarction, with concomitant decreased delivery to many off-target organs, including the liver.

Original language	English (US)
Pages (from-to)	611-622
Number of pages	12
Journal	Molecular Therapy
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.ymthe.2019.01.015
State	Published - Mar 6 2019
Externally published	Yes

Keywords

AAV
activatable
adeno-associated virus
cardiac gene therapy
gene delivery
gene therapy
inflammation targeting
matrix metalloproteinase
myocardial infarction
provector
stimulus responsive
viral vector

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Pharmacology
Drug Discovery

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10.1016/j.ymthe.2019.01.015

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Guenther, C. M., Brun, M. J., Bennett, A. D., Ho, M. L., Chen, W., Zhu, B., Lam, M., Yamagami, M., Kwon, S., Bhattacharya, N., Sousa, D., Evans, A. C., Voss, J., Sevick-Muraca, E. M., Agbandje-McKenna, M., & Suh, J. (2019). Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue. Molecular Therapy, 27(3), 611-622. https://doi.org/10.1016/j.ymthe.2019.01.015

Guenther, CM, Brun, MJ, Bennett, AD, Ho, ML, Chen, W, Zhu, B, Lam, M, Yamagami, M, Kwon, S, Bhattacharya, N, Sousa, D, Evans, AC, Voss, J, Sevick-Muraca, EM, Agbandje-McKenna, M & Suh, J 2019, 'Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue', Molecular Therapy, vol. 27, no. 3, pp. 611-622. https://doi.org/10.1016/j.ymthe.2019.01.015

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abstract = "Guenther et al. have developed a protease-activatable AAV provector to target diseased tissue microenvironments exhibiting elevated extracellular protease activity. The provector delivers transgenes to high-MMP-activity regions of the damaged heart following a myocardial infarction, with concomitant decreased delivery to many off-target organs, including the liver.",

keywords = "AAV, activatable, adeno-associated virus, cardiac gene therapy, gene delivery, gene therapy, inflammation targeting, matrix metalloproteinase, myocardial infarction, provector, stimulus responsive, viral vector",

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doi = "10.1016/j.ymthe.2019.01.015",

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AU - Guenther, Caitlin M.

AU - Brun, Mitchell J.

AU - Bennett, Antonette D.

AU - Ho, Michelle L.

AU - Chen, Weitong

AU - Zhu, Banghe

AU - Lam, Michael

AU - Yamagami, Momona

AU - Kwon, Sunkuk

AU - Bhattacharya, Nilakshee

AU - Sousa, Duncan

AU - Evans, Annicka C.

AU - Voss, Julie

AU - Sevick-Muraca, Eva M.

AU - Agbandje-McKenna, Mavis

AU - Suh, Junghae

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KW - AAV

KW - activatable

KW - adeno-associated virus

KW - cardiac gene therapy

KW - gene delivery

KW - gene therapy

KW - inflammation targeting

KW - matrix metalloproteinase

KW - myocardial infarction

KW - provector

KW - stimulus responsive

KW - viral vector

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Protease-Activatable Adeno-Associated Virus Vector for Gene Delivery to Damaged Heart Tissue

Abstract

Keywords

ASJC Scopus subject areas

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