TY - JOUR
T1 - Prostate-specific antigen velocity and repeated measures of prostate- specific antigen
AU - Carter, H. B.
AU - Pearson, J. D.
N1 - Funding Information:
This article is supported by the Longitudinal Studies Branch, Baltimore Longitudinal Study of Aging, The National Institute of Aging.
PY - 1997
Y1 - 1997
N2 - Numerous studies evaluating different populations have shown similar findings with respect to repeated PSA measurements and PSAV. First, there is substantial within-individual variability between repeated PSA measures. Second, this variability between PSA measurements precludes the use of a simple change in PSA as a marker for prostate cancer. Third, when one adjusts the changes that occur in PSA over an elapsed time of 1.5 to 2 years (PSAV), less than 5% of men without prostate, cancer will have a PSAV of 0.75 ng/mL/y or greater, and approximately 70% of men with prostate cancer will have a PSAV of 0.75 ng/mL/y or greater. These data strongly suggest that PSAV is a specific marker for the presence of prostate cancer.
AB - Numerous studies evaluating different populations have shown similar findings with respect to repeated PSA measurements and PSAV. First, there is substantial within-individual variability between repeated PSA measures. Second, this variability between PSA measurements precludes the use of a simple change in PSA as a marker for prostate cancer. Third, when one adjusts the changes that occur in PSA over an elapsed time of 1.5 to 2 years (PSAV), less than 5% of men without prostate, cancer will have a PSAV of 0.75 ng/mL/y or greater, and approximately 70% of men with prostate cancer will have a PSAV of 0.75 ng/mL/y or greater. These data strongly suggest that PSAV is a specific marker for the presence of prostate cancer.
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U2 - 10.1016/S0094-0143(05)70380-3
DO - 10.1016/S0094-0143(05)70380-3
M3 - Article
C2 - 9126231
AN - SCOPUS:0030993375
SN - 0094-0143
VL - 24
SP - 333
EP - 338
JO - Urologic Clinics of North America
JF - Urologic Clinics of North America
IS - 2
ER -