Prostate-specific antigen levels among cirrhotic patients

Meral Akdogan, B. S. Hassoun, Ahmet Gurakar, K. El-Sahwi, A. Jazzar, H. Wright, A. Sebastian, B. Nour

Research output: Contribution to journalArticle

Abstract

Purpose: The aim of this study was to determine serum prostate-specific antigen (PSA) levels in patients with liver cirrhosis. Patients and methods: Between January 1995 and August 2001, 216 men with cirrhosis were evaluated. The extent of their liver disease was classified according to the Child-Pugh classification. Serum PSA levels were measured with the Hybritech Tandem-R RIA method and matched with age-related reference PSA levels. Digital rectal examination (DRE) was performed in all patients. Patients with elevated PSA levels and/or abnormal DRE were recommended to undergo further assessment including transrectal ultrasonography (TRUS) and biopsy performed by an urologist. Results: Two hundred and sixteen men (mean age 54.09±9.09 years, range 25-76) with cirrhosis were examined. Their mean PSA value was 0.57±0.84 ng/mL and tended to be lower than in the normal population. The degree of PSA decrease was found to parallel the severity of the liver disease (p=0.002). The mean serum PSA level increased with each age decade in a statistically significant manner (p

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalInternational Journal of Biological Markers
Volume17
Issue number3
StatePublished - Jul 2002
Externally publishedYes

Fingerprint

Prostate-Specific Antigen
Liver
Digital Rectal Examination
Liver Diseases
Fibrosis
Serum
Ultrasonography
Biopsy
Liver Cirrhosis
Population

Keywords

  • Liver cirrhosis
  • Prostate-specific antigen

ASJC Scopus subject areas

  • Immunology
  • Biochemistry

Cite this

Akdogan, M., Hassoun, B. S., Gurakar, A., El-Sahwi, K., Jazzar, A., Wright, H., ... Nour, B. (2002). Prostate-specific antigen levels among cirrhotic patients. International Journal of Biological Markers, 17(3), 161-164.

Prostate-specific antigen levels among cirrhotic patients. / Akdogan, Meral; Hassoun, B. S.; Gurakar, Ahmet; El-Sahwi, K.; Jazzar, A.; Wright, H.; Sebastian, A.; Nour, B.

In: International Journal of Biological Markers, Vol. 17, No. 3, 07.2002, p. 161-164.

Research output: Contribution to journalArticle

Akdogan, M, Hassoun, BS, Gurakar, A, El-Sahwi, K, Jazzar, A, Wright, H, Sebastian, A & Nour, B 2002, 'Prostate-specific antigen levels among cirrhotic patients', International Journal of Biological Markers, vol. 17, no. 3, pp. 161-164.
Akdogan M, Hassoun BS, Gurakar A, El-Sahwi K, Jazzar A, Wright H et al. Prostate-specific antigen levels among cirrhotic patients. International Journal of Biological Markers. 2002 Jul;17(3):161-164.
Akdogan, Meral ; Hassoun, B. S. ; Gurakar, Ahmet ; El-Sahwi, K. ; Jazzar, A. ; Wright, H. ; Sebastian, A. ; Nour, B. / Prostate-specific antigen levels among cirrhotic patients. In: International Journal of Biological Markers. 2002 ; Vol. 17, No. 3. pp. 161-164.
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AU - Sebastian, A.

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