Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration

S. Sutcliffe; R. L. Nevin; R. Pakpahan; D. J. Elliott; S. R. Cole; A. M. De Marzo; C. A. Gaydos; W. B. Isaacs; W. G. Nelson; L. J. Sokoll; J. M. Zenilman; S. B. Cersovsky; E. A. Platz

doi:10.1038/bjc.2011.271

Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration

S. Sutcliffe, R. L. Nevin, R. Pakpahan, D. J. Elliott, S. R. Cole, A. M. De Marzo, C. A. Gaydos, W. B. Isaacs, W. G. Nelson, L. J. Sokoll, J. M. Zenilman, S. B. Cersovsky, E. A. Platz

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members. Methods: We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls. Results: Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P0.0001, 0.021, and 0.92, respectively). Conclusion: Chlamydia and gonorrhoea may infect the prostate of some infected men.

Original language	English (US)
Pages (from-to)	602-605
Number of pages	4
Journal	British journal of cancer
Volume	105
Issue number	5
DOIs	https://doi.org/10.1038/bjc.2011.271
State	Published - Aug 23 2011

Keywords

chlamydia
gonorrhoea
non-chlamydial
non-gonococcal urethritis
prostate cancer
prostate-specific antigen
sexually transmitted infections

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/bjc.2011.271

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Sutcliffe, S., Nevin, R. L., Pakpahan, R., Elliott, D. J., Cole, S. R., De Marzo, A. M., Gaydos, C. A., Isaacs, W. B., Nelson, W. G., Sokoll, L. J., Zenilman, J. M., Cersovsky, S. B., & Platz, E. A. (2011). Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration. British journal of cancer, 105(5), 602-605. https://doi.org/10.1038/bjc.2011.271

Sutcliffe, S, Nevin, RL, Pakpahan, R, Elliott, DJ, Cole, SR, De Marzo, AM , Gaydos, CA , Isaacs, WB , Nelson, WG , Sokoll, LJ , Zenilman, JM, Cersovsky, SB & Platz, EA 2011, 'Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration', British journal of cancer, vol. 105, no. 5, pp. 602-605. https://doi.org/10.1038/bjc.2011.271

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abstract = "Background: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members. Methods: We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls. Results: Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P0.0001, 0.021, and 0.92, respectively). Conclusion: Chlamydia and gonorrhoea may infect the prostate of some infected men.",

keywords = "chlamydia, gonorrhoea, non-chlamydial, non-gonococcal urethritis, prostate cancer, prostate-specific antigen, sexually transmitted infections",

author = "S. Sutcliffe and Nevin, {R. L.} and R. Pakpahan and Elliott, {D. J.} and Cole, {S. R.} and {De Marzo}, {A. M.} and Gaydos, {C. A.} and Isaacs, {W. B.} and Nelson, {W. G.} and Sokoll, {L. J.} and Zenilman, {J. M.} and Cersovsky, {S. B.} and Platz, {E. A.}",

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doi = "10.1038/bjc.2011.271",

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AU - Nevin, R. L.

AU - Pakpahan, R.

AU - Elliott, D. J.

AU - Cole, S. R.

AU - De Marzo, A. M.

AU - Gaydos, C. A.

AU - Isaacs, W. B.

AU - Nelson, W. G.

AU - Sokoll, L. J.

AU - Zenilman, J. M.

AU - Cersovsky, S. B.

AU - Platz, E. A.

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N2 - Background: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members. Methods: We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls. Results: Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P0.0001, 0.021, and 0.92, respectively). Conclusion: Chlamydia and gonorrhoea may infect the prostate of some infected men.

AB - Background: We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members. Methods: We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls. Results: Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P0.0001, 0.021, and 0.92, respectively). Conclusion: Chlamydia and gonorrhoea may infect the prostate of some infected men.

KW - chlamydia

KW - gonorrhoea

KW - non-chlamydial

KW - non-gonococcal urethritis

KW - prostate cancer

KW - prostate-specific antigen

KW - sexually transmitted infections

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Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration

Abstract

Keywords

ASJC Scopus subject areas

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