Prostate gland motion assessed with cine-magnetic resonance imaging (cine-MRI)

Michel J. Ghilezan, David A. Jaffray, Jeffrey H. Siewerdsen, Marcel Van Herk, Anil Shetty, Michael B. Sharpe, Syed Zafar Jafri, Frank A. Vicini, Richard C. Matter, Donald S. Brabbins, Alvaro A. Martinez

Research output: Contribution to journalArticle

Abstract

Purpose: To quantify prostate motion during a radiation therapy treatment using cine-magnetic resonance imaging (cine-MRI) for time frames comparable to that expected in an image-guided radiation therapy treatment session (20-30 min). Materials and Methods: Six patients undergoing radiation therapy for prostate cancer were imaged on 3 days, over the course of therapy (Weeks 1, 3, and 5). Four hundred images were acquired during the 1-h MRI session in 3 sagittal planes through the prostate at 6-s intervals. Eleven anatomic points of interest (POIs) have been used to characterize prostate/bony pelvis/abdominal wall displacement. Motion traces and standard deviation for each of the 11 POIs have been determined. The probability of displacement over time has also been calculated. Results: Patients were divided into 2 groups according to rectal filling status: full vs. empty rectum. The displacement of POIs (standard deviation) ranged from 0.98 to 1.72 mm for the full-rectum group and from 0.68 to 1.04 mm for the empty-rectum group. The low standard deviations in position (2 mm or less) would suggest that these excursions have a low frequency of occurrence. The most sensitive prostate POI to rectal wall motion was the midposterior with a standard deviation of 1.72 mm in the full-rectum group vs. 0.79 mm in the empty-rectum group (p = 0.0001). This POI has a 10% probability of moving more than 3 mm in a time frame of ∼1 min if the rectum is full vs. ∼20 min if the rectum is empty. Conclusion: Motion of the prostate and seminal vesicles during a time frame similar to a standard treatment session is reduced compared to that reported in interfraction studies. The most significant predictor for intrafraction prostate motion is the status of rectal filling. A prostate displacement of <3 mm (90%) can be expected for the 20 min after the moment of initial imaging for patients with an empty rectum. This is not the case for patients presenting with full rectum. The determination of appropriate intrafraction margins in radiation therapy to accommodate the time-dependent uncertainty in positional targeting is a topic of ongoing investigations for the on-line image guidance model.

Original languageEnglish (US)
Pages (from-to)406-417
Number of pages12
JournalInternational Journal of Radiation Oncology Biology Physics
Volume62
Issue number2
DOIs
StatePublished - Jun 1 2005

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Keywords

  • Cine-MRI
  • Intrafraction
  • Organ motion
  • Prostate cancer
  • Radiation therapy

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Ghilezan, M. J., Jaffray, D. A., Siewerdsen, J. H., Van Herk, M., Shetty, A., Sharpe, M. B., Jafri, S. Z., Vicini, F. A., Matter, R. C., Brabbins, D. S., & Martinez, A. A. (2005). Prostate gland motion assessed with cine-magnetic resonance imaging (cine-MRI). International Journal of Radiation Oncology Biology Physics, 62(2), 406-417. https://doi.org/10.1016/j.ijrobp.2003.10.017